Learn About Gastroschisis

What is the definition of Gastroschisis?

Gastroschisis is a birth defect in which an infant's intestines are outside of the body because of a hole in the abdominal wall.

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What are the alternative names for Gastroschisis?

Birth defect - gastroschisis; Abdominal wall defect - infant; Abdominal wall defect - neonate; Abdominal wall defect - newborn

What are the causes of Gastroschisis?

Babies with gastroschisis are born with a hole in the abdominal wall. The child's intestines often stick out (protrude) through the hole.

The condition looks similar to an omphalocele. An omphalocele, however, is a birth defect in which the infant's intestine or other abdominal organs protrude through a hole in the belly button area and are covered with a membrane. With gastroschisis, there is no covering membrane.

Abdominal wall defects develop as a baby grows inside the mother's womb. During development, the intestine and other organs (liver, bladder, stomach, and ovaries, or testes) develop outside the body at first and then usually return inside. In babies with gastroschisis, the intestines (and sometimes the stomach) remain outside the abdominal wall, without a membrane covering them. The exact cause of abdominal wall defects is not known.

Mothers with the following may be at higher risk of having babies with gastroschisis:

  • Younger age
  • Fewer resources
  • Poor nutrition during pregnancy
  • Use of tobacco, cocaine, or methamphetamines
  • Exposure to nitrosamine (chemical found in some foods, cosmetics, cigarettes)
  • Use of aspirin, ibuprofen, acetaminophen
  • Use of decongestants that have the chemical pseudoephedrine or phenylpropanolamine

Babies with gastroschisis usually do not have other related birth defects.

What are the symptoms of Gastroschisis?

A gastroschisis is usually seen during a prenatal ultrasound. It can also be seen when the baby is born. There is a hole in the abdominal wall. The small intestine is often outside the abdomen near the umbilical cord. Other organs that may also be outside the abdomen are the large intestine, stomach, and/or gallbladder.

Usually the intestine is irritated by the exposure to amniotic fluid. The baby may have problems absorbing food.

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What are the current treatments for Gastroschisis?

If gastroschisis is found before birth, the mother will need special monitoring to make sure her unborn baby remains healthy.

Treatment for gastroschisis involves surgery. Usually the infant's abdominal cavity is too small for the intestine to fit back in at birth. So a mesh sack is stitched around the borders of the defect and the edges of the defect are pulled up. The sack is called a silo. Over the next week or two, the intestine returns into the abdominal cavity and the defect can then be closed.

The baby's temperature must be carefully controlled, because the exposed intestine allows body heat to escape. Because of the pressure involved in returning the intestines to the abdomen, the baby may need breathing support with a ventilator. Other treatments for the baby include nutrients by IV and antibiotics to prevent infection. Even after the defect is closed, IV nutrition will continue as milk feedings must be introduced slowly.

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What is the outlook (prognosis) for Gastroschisis?

The baby has a good chance of recovering if there are no other problems and if the abdominal cavity is large enough. A very small abdominal cavity may result in complications that require more surgeries.

Plans should be made for careful delivery and immediate management of the problem after birth. The baby should be delivered in a medical center that is skilled at repairing abdominal wall defects. Babies are likely to do better if they do not need to be taken to another center for further treatment.

What are the possible complications of Gastroschisis?

Because of the exposure to amniotic fluid, babies' intestines may not work normally even after the organs are put back inside the abdominal cavity. Babies with gastroschisis need time for their intestines to recover and become used to taking feedings.

A small number of babies with gastroschisis (about 10 to 20%) may have intestinal atresia (parts of the intestines that did not develop in the womb). These babies require further surgery to relieve obstruction.

The increased pressure from the misplaced abdominal contents can decrease blood flow to the intestines and kidneys and cause more long-term damage. It can also make it difficult for the baby to expand the lungs, leading to breathing problems.

Another possible complication is bowel death necrosis. This occurs when intestinal tissue dies due to low blood flow or infection. This risk may be reduced in babies who receive breast milk rather than formula.

This condition (gastroschisis) is apparent at birth and will be detected in the hospital at delivery if it has not already been seen on routine fetal ultrasound exams during pregnancy. If you have given birth at home and your baby appears to have this defect, call the local emergency number (such as 911) right away.

When should I contact a medical professional for Gastroschisis?

This problem is diagnosed and treated in the hospital right after birth. After returning home, contact your health care provider if your baby develops any of these symptoms:

  • Decreased bowel movements
  • Feeding problems
  • Fever
  • Green or yellowish green vomit
  • Swollen belly area
  • Vomiting (different than normal baby spit-up)
  • Worrisome behavioral changes
Infant abdominal hernia (gastroschisis)
Gastroschisis repair - series
Silo
What are the latest Gastroschisis Clinical Trials?
Gastroschisis Outcomes of Delivery (GOOD) Study

Summary: The objective of this study is to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectant management with a goal of delivery at 38 0/7 - 38 6/7 weeks. To test this hypothesis, we will complete a randomized, prospective, multi-institutional trial across NAFTNet-affiliated institutions. Patients may be enrolled i...

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A Prospective Tolerability and Safety Study of a Powdered Human Milk-based Breastmilk Fortifier (Neokare) in Neonates With Gastrointestinal Problems

Summary: With an increasing body of evidence to support a causal link between drinking milk that contain cow's milk protein (CMP) and the development of gastrointestinal disturbance in infants, many clinicians avoid the use of CMP containing feed in high risk babies. Delivery of adequate nutritional intake is one of the great challenges in the care of newborn infants, particularly those born preterm or wit...

What are the Latest Advances for Gastroschisis?
Comparative Study between Acacia Nilotica versus Povidone Iodine in Topical Treatment of Omphalocele Major.
Preterm vs term delivery in antenatally diagnosed gastroschisis: a systematic review and meta-analysis.
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Who are the sources who wrote this article ?

Published Date: November 09, 2021
Published By: Kimberly G. Lee, MD, MSc, IBCLC, Clinical Professor of Pediatrics, Division of Neonatology, Medical University of South Carolina, Charleston, SC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Islam S. Congenital abdominal wall defects: gastroschisis and omphalocele. In: Holcomb GW, Murphy P, St. Peter SD, Gatti JM, eds. Holcomb and Ashcraft's Pediatric Surgery. 7th ed. Philadelphia, PA: Elsevier; 2020:chap 48.

Polites S, Nathan JD. Newborn abdominal wall defects. In: Wyllie R, Hyams JS, Kay M, eds. Pediatric Gastrointestinal and Liver Disease. 6th ed. Philadelphia, PA: Elsevier; 2021:chap 58.