Generalized Resistance to Thyroid Hormone
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Generalized Resistance to Thyroid Hormone Overview

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What is the definition of Generalized Resistance to Thyroid Hormone?
Generalized resistance to thyroid hormone (GRTH), is a rare genetic condition characterized by hyperthyroidism (overactive thyroid) and reduced body tissue response to thyroid hormone.
What are the symptoms of Generalized Resistance to Thyroid Hormone?
Some individuals with generalized resistance to thyroid hormone may not have any symptoms. Symptoms of generalized resistance to thyroid hormone may include goiter (swelling of the neck), rapid heartbeat (tachycardia), delayed bone maturation, osteoporosis, growth retardation, short stature, mental retardation, recurrent ear infections, sensorineural deafness, repetitive, uncontrolled eye movements (nystagmus), learning disabilities, and attention deficit hyperactivity disorder (ADHD).
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What are the current treatments for Generalized Resistance to Thyroid Hormone?
There is no cure for generalized resistance to thyroid hormone. Because individuals with this disorder have increased blood levels of T4 and T3 thyroid hormones, treatment is usually not necessary. However, when treatment for goiter, rapid heartbeat, or tremor associated with generalized resistance to thyroid hormone are necessary, the thyroid hormone medication, liothyronine (T3) or the beta adrenergic blocker, atenolol may be prescribed. Attention deficit hyperactivity disorder associated with generalized resistance to thyroid hormone is treated with the usual medications. Some individuals with generalized resistance to thyroid hormone may also be prescribed the thyroid hormone, levothyroxine (T4).
Who are the top Generalized Resistance to Thyroid Hormone Local Doctors?
Advanced in Generalized Resistance to Thyroid Hormone
Dr. Matthew D. Beasey
Endocrinology
Advanced in Generalized Resistance to Thyroid Hormone
Dr. Matthew D. Beasey
Endocrinology
Referral required

Ballad Health Medical Associates Diabetes And Endocrinology Center

16000 Johnston Memorial Drive, Suite 112, 
Abingdon, VA 
276-258-3780
Languages Spoken:
English
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Matthew Beasey is an Endocrinologist practicing medicine in Abingdon, Virginia. Dr. Beasey is rated as an Advanced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. He is also highly rated in 30 other conditions, according to our data. His clinical expertise encompasses Type 2 Diabetes (T2D), Diabetic Neuropathy, Maturity Onset Diabetes of the Young, and Type 1 Diabetes (T1D). Dr. Beasey is board certified in American Board Of Pediatrics and American Board Of Internal Medicine.

Elite in Generalized Resistance to Thyroid Hormone
Carla M. Moran
Elite in Generalized Resistance to Thyroid Hormone
Carla M. Moran
Referral may be required

St. Vincent's University Hospital, Elm Park

Park, C, IE 

Carla Moran practices practicing medicine in Park, Ireland. Ms. Moran is rated as an Elite expert by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. She is also highly rated in 9 other conditions, according to our data. Her clinical expertise encompasses Hyperthyroidism, Generalized Resistance to Thyroid Hormone, Familial Hyperthyroidism due to Mutations in TSH Receptor, Thyroidectomy, and Parathyroidectomy.

 
 
 
 
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Elite in Generalized Resistance to Thyroid Hormone
Luca G. Persani
Elite in Generalized Resistance to Thyroid Hormone
Luca G. Persani
Referral may be required
Milan, IT 

Luca Persani practices practicing medicine in Milan, Italy. Mr. Persani is rated as an Elite expert by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. He is also highly rated in 40 other conditions, according to our data. His clinical expertise encompasses Hypothyroidism, Congenital Hypothyroidism, Premature Ovarian Failure, Hormone Replacement Therapy (HRT), and Thyroidectomy.

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What are the latest Generalized Resistance to Thyroid Hormone Clinical Trials?
Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Enrollment Status: Recruiting
Publish Date: September 02, 2025
Intervention Type: Genetic, Diagnostic test

Summary: The goal of this observational study is to learn about the neurological and cardiological phenotype of patients with resistance to thyroid hormone (RTH) syndromes beta and alpha (RTHß and RTHa) due to dominant negative variants in the genes encoding the thyroid hormone receptors alpha (THRA) and beta (THRB). The main question\[s\] it aims to answer are: * Define frequency and improve early diagnos...

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Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Enrollment Status: Recruiting
Publish Date: August 22, 2024
Intervention Type: Other

Summary: Thyroid hormones (TH) play a pivotal role in the development and function of the mammalian brain. Patients with impaired thyroid hormone transport into the brain tissue or in the case of defective local thyroid hormone receptor (collectively referred to as thyroid hormone resistance) subsequently experience psychomotor disabilities. The DEEPTYPE registry has been established with the objective of ...

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