Generalized Resistance to Thyroid Hormone Overview

Save information for later
Sign Up

Learn About Generalized Resistance to Thyroid Hormone

What is the definition of Generalized Resistance to Thyroid Hormone?
Generalized resistance to thyroid hormone (GRTH), is a rare genetic condition characterized by hyperthyroidism (overactive thyroid) and reduced body tissue response to thyroid hormone.
What are the symptoms of Generalized Resistance to Thyroid Hormone?
Some individuals with generalized resistance to thyroid hormone may not have any symptoms. Symptoms of generalized resistance to thyroid hormone may include goiter (swelling of the neck), rapid heartbeat (tachycardia), delayed bone maturation, osteoporosis, growth retardation, short stature, mental retardation, recurrent ear infections, sensorineural deafness, repetitive, uncontrolled eye movements (nystagmus), learning disabilities, and attention deficit hyperactivity disorder (ADHD).
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Generalized Resistance to Thyroid Hormone?
There is no cure for generalized resistance to thyroid hormone. Because individuals with this disorder have increased blood levels of T4 and T3 thyroid hormones, treatment is usually not necessary. However, when treatment for goiter, rapid heartbeat, or tremor associated with generalized resistance to thyroid hormone are necessary, the thyroid hormone medication, liothyronine (T3) or the beta adrenergic blocker, atenolol may be prescribed. Attention deficit hyperactivity disorder associated with generalized resistance to thyroid hormone is treated with the usual medications. Some individuals with generalized resistance to thyroid hormone may also be prescribed the thyroid hormone, levothyroxine (T4).
Who are the top Generalized Resistance to Thyroid Hormone Local Doctors?
Elite in Generalized Resistance to Thyroid Hormone
Carla M. Moran
Elite in Generalized Resistance to Thyroid Hormone
Carla M. Moran

St. Vincent's University Hospital, Elm Park

Park, C, IE 

Carla Moran practices in Park, Ireland. Ms. Moran is rated as an Elite expert by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. Her top areas of expertise are Hyperthyroidism, Generalized Resistance to Thyroid Hormone, Familial Hyperthyroidism due to Mutations in TSH Receptor, Thyroidectomy, and Parathyroidectomy.

Elite in Generalized Resistance to Thyroid Hormone
Luca G. Persani
Elite in Generalized Resistance to Thyroid Hormone
Luca G. Persani
Milan, IT 

Luca Persani practices in Milan, Italy. Mr. Persani is rated as an Elite expert by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. His top areas of expertise are Hypothyroidism, Congenital Hypothyroidism, Premature Ovarian Failure, Hormone Replacement Therapy (HRT), and Thyroidectomy.

 
 
 
 
Learn about our expert tiers
Learn More
Advanced in Generalized Resistance to Thyroid Hormone
Dr. Wagdy F. Girgis
Family Medicine
Advanced in Generalized Resistance to Thyroid Hormone
Dr. Wagdy F. Girgis
Family Medicine

Wagdy F Girgis MD PC

76 Battery Ave, 
Brooklyn, NY 
718-836-5607
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Wagdy Girgis is a primary care provider, practicing in Family Medicine in Brooklyn, New York. Dr. Girgis is rated as an Advanced provider by MediFind in the treatment of Generalized Resistance to Thyroid Hormone. His top areas of expertise are Peptic Ulcer, Cellulitis, Necrosis, and Varicose Veins.

View All Doctors
What are the latest Generalized Resistance to Thyroid Hormone Clinical Trials?
Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Advancing Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects (ADAM-THAD)
Enrollment Status: Recruiting
Publish Date: September 02, 2025
Intervention Type: Genetic, Diagnostic test

Summary: The goal of this observational study is to learn about the neurological and cardiological phenotype of patients with resistance to thyroid hormone (RTH) syndromes beta and alpha (RTHß and RTHa) due to dominant negative variants in the genes encoding the thyroid hormone receptors alpha (THRA) and beta (THRB). The main question\[s\] it aims to answer are: * Define frequency and improve early diagnos...

Match to trials
Find the right clinical trials for you in under a minute
Get started
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Deep Geno- and Phenotyping of Patients With Thyroid Hormone Resistance, a Register Study.
Enrollment Status: Recruiting
Publish Date: August 22, 2024
Intervention Type: Other

Summary: Thyroid hormones (TH) play a pivotal role in the development and function of the mammalian brain. Patients with impaired thyroid hormone transport into the brain tissue or in the case of defective local thyroid hormone receptor (collectively referred to as thyroid hormone resistance) subsequently experience psychomotor disabilities. The DEEPTYPE registry has been established with the objective of ...

View All Clinical Trials