Learn About Genetic Epilepsy with Febrile Seizures Plus (GEFS+)

What is the definition of Genetic Epilepsy with Febrile Seizures Plus (GEFS+)?

Genetic epilepsy with febrile seizures plus (GEFS+) is a spectrum of seizure disorders of varying severity. GEFS+ is usually diagnosed in families whose members have a combination of febrile seizures, which are triggered by a high fever, and recurrent seizures (epilepsy) of other types, including seizures that are not related to fevers (afebrile seizures). The additional seizure types usually involve both sides of the brain (generalized seizures); however, seizures that involve only one side of the brain (partial seizures) occur in some affected individuals. The most common types of seizure in people with GEFS+ include myoclonic seizures, which cause involuntary muscle twitches; atonic seizures, which involve sudden episodes of weak muscle tone; and absence seizures, which cause loss of consciousness for short periods that appear as staring spells.

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What are the causes of Genetic Epilepsy with Febrile Seizures Plus (GEFS+)?

Mutations in several genes, including some that have not been identified, can cause GEFS+. The most commonly associated gene is SCN1A. More than 80 percent of Dravet syndrome cases and about 10 percent of other GEFS+ cases are caused by changes in this gene. Mutations in other genes have been found in only a small number of affected individuals or families.

How prevalent is Genetic Epilepsy with Febrile Seizures Plus (GEFS+)?

GEFS+ is a rare condition. Its prevalence is unknown.

Is Genetic Epilepsy with Febrile Seizures Plus (GEFS+) an inherited disorder?

GEFS+ is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

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What are the latest Genetic Epilepsy with Febrile Seizures Plus (GEFS+) Clinical Trials?
Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital

Summary: Febrile seizures are one of the most common clinical diseases in pediatric neurology. It occurs between 6 months and 6 years of age and occurs in 2-5% of children. According to the age, frequency, duration, and type of seizures FS is divided into simple febrile seizures and complex febrile seizures Differentiation between febrile seizures and non-ictal events associated with fever such as shiverin...

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The Efficacy of A Single Dose Clonazepam Compared With the Intermittent Diazepam to Prevent Recurrent Febrile Seizures in Queen Sirikit National Institute of Child Health

Summary: To study the efficacy and safety of single dose clonazepam compared with intermittent oral diazepam for prevention of recurrent febrile seizures in children who had three or more febrile seizures.

Who are the sources who wrote this article ?

Published Date: July 01, 2017Published By: National Institutes of Health

What are the Latest Advances for Genetic Epilepsy with Febrile Seizures Plus (GEFS+)?
Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures.
Sodium voltage-gated channel alpha subunit 9 mutation in epilepsy.
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Evaluation of risk factors associated with first episode febrile seizure.