Learn About Genetic Epilepsy with Febrile Seizures Plus

What is the definition of Genetic Epilepsy with Febrile Seizures Plus?

Genetic epilepsy with febrile seizures plus (GEFS+) is a spectrum of seizure disorders of varying severity. GEFS+ is usually diagnosed in families whose members have a combination of febrile seizures, which are triggered by a high fever, and recurrent seizures (epilepsy) of other types, including seizures that are not related to fevers (afebrile seizures). The additional seizure types usually involve both sides of the brain (generalized seizures); however, seizures that involve only one side of the brain (partial seizures) occur in some affected individuals. The most common types of seizure in people with GEFS+ include myoclonic seizures, which cause involuntary muscle twitches; atonic seizures, which involve sudden episodes of weak muscle tone; and absence seizures, which cause loss of consciousness for short periods that appear as staring spells.

Save information for later
Sign Up
What are the causes of Genetic Epilepsy with Febrile Seizures Plus?

Mutations in several genes, including some that have not been identified, can cause GEFS+. The most commonly associated gene is SCN1A. More than 80 percent of Dravet syndrome cases and about 10 percent of other GEFS+ cases are caused by changes in this gene. Mutations in other genes have been found in only a small number of affected individuals or families.

How prevalent is Genetic Epilepsy with Febrile Seizures Plus?

GEFS+ is a rare condition. Its prevalence is unknown.

Is Genetic Epilepsy with Febrile Seizures Plus an inherited disorder?

GEFS+ is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

Who are the top Genetic Epilepsy with Febrile Seizures Plus Local Doctors?
Elite
Highly rated in
14
conditions

Ministry Of Health And Social Services Of Quebec

CA 

Lionel Carmant is in Canada. Carmant is rated as an Elite expert by MediFind in the treatment of Genetic Epilepsy with Febrile Seizures Plus. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Genetic Epilepsy with Febrile Seizures Plus, Seizures, Epilepsy, and Epilepsy in Children.

Elite
Highly rated in
64
conditions

University Of Melbourne

Melbourne, VIC, AU 

Ingrid Scheffer is in Melbourne, Australia. Scheffer is rated as an Elite expert by MediFind in the treatment of Genetic Epilepsy with Febrile Seizures Plus. She is also highly rated in 64 other conditions, according to our data. Her top areas of expertise are Epilepsy, Epilepsy with Myoclonic-Atonic Seizures, Myoclonus Epilepsy Partial Seizure, and Myoclonic Epilepsy.

 
 
 
 
Learn about our expert tiers
Learn more
Elite
Highly rated in
79
conditions

Anna Meyer Children's Hospital

IT 

Renzo Guerrini is in Italy. Guerrini is rated as an Elite expert by MediFind in the treatment of Genetic Epilepsy with Febrile Seizures Plus. He is also highly rated in 79 other conditions, according to our data. His top areas of expertise are Polymicrogyria, Cortical Dysplasia, Lissencephaly, and Epilepsy.

What are the latest Genetic Epilepsy with Febrile Seizures Plus Clinical Trials?
Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital
Match to trials
Find the right clinical trials for you in under a minute
Get started
Serum Levels of Adipocytokines in Children With Febrile Seizures: A Cross-Sectional Study at Sohag University Hospital
Who are the sources who wrote this article ?

Published Date:updated Last, July

Published By: National Institutes of Health

What are the Latest Advances for Genetic Epilepsy with Febrile Seizures Plus?
Sodium voltage-gated channel alpha subunit 9 mutation in epilepsy.
Evaluation of risk factors associated with first episode febrile seizure.
Tired of the same old research?
Check Latest Advances
A novel de novo hemizygous ARHGEF9 mutation associated with severe intellectual disability and epilepsy: a case report.