Geographic Atrophy Clinical Trials

∙ Male or female participants ≥ 50 years of age.

• A diagnosis of GA secondary to AMD in at least one eye (study eye). If both eyes qualify, then the eye with the better BCVA would be assigned as study eye.

‣ Total GA area must be ≥2.5 and ≤17.5 mm2 (1 and 7 disk areas (DA), respectively)

⁃ If GA lesion is multifocal, then the total lesion area must be between 2.5-17.5 mm2 and at least one lesion should have an area of at least 1.25 mm2

⁃ Entire GA lesion must be visualized on the macula centered image and not contiguous with peripapillary atrophy

• ETDRS BCVA ≥ 35 letters (20/200) in the study eye.