The Early and Late Contribution of Fasting and Postprandial Triglycerides on Newborn Subcutaneous and Intrahepatic Fat in Pregnancy

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

This study plans to learn more about how triglyceride levels in pregnancy affect newborn fat mass. Obesity in pregnancy, in the absence of gestational diabetes, is now the most common cause of large-for-gestational-age infants and increased newborn fat mass. Previous data supports the idea that maternal triglycerides, not glucose, are the strongest predictor of both total newborn fat mass and liver fat. In this study, mothers will monitor triglyceride and glucose levels at specific points in pregnancy using point-of-care meters at home. Two weeks after birth, infants will have total fat measured by air-displacement plethysmography (PEAPOD) and liver fat measures by Magnetic Resonance Spectroscopy (MRS). The central hypothesis is that in obesity, fasting triglycerides and postprandial triglycerides will predict newborn fat mass in a free-living environment.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 39
Healthy Volunteers: t
View:

• Pregnant women less than 16 weeks gestational age

• Between the ages of 21-39 years

• Pre-pregnancy BMI 28-39 kg/m2

Locations
United States
Colorado
University of Colorado/Anschutz Medical Campus
RECRUITING
Aurora
Contact Information
Primary
Emily Z Dunn, MS, RDN
Emily.2.Dunn@cuanschutz.edu
303-724-0320
Backup
Nicole Hirsch, MS
Nicole.Hirsch@cuanschutz.edu
303-724-0572
Time Frame
Start Date: 2022-03-01
Estimated Completion Date: 2027-07
Participants
Target number of participants: 140
Related Therapeutic Areas
Sponsors
Leads: University of Colorado, Denver

This content was sourced from clinicaltrials.gov