Learn About Gianotti-Crosti Syndrome

What is the definition of Gianotti-Crosti Syndrome?

Gianotti-Crosti syndrome is a childhood skin condition that may be accompanied by mild symptoms of fever and malaise. It may also be associated with hepatitis B and other viral infections.

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What are the alternative names for Gianotti-Crosti Syndrome?

Papular acrodermatitis of childhood; Infantile acrodermatitis; Acrodermatitis - infantile lichenoid; Acrodermatitis - papular infantile; Papulovesicular acro-located syndrome

What are the causes of Gianotti-Crosti Syndrome?

Health care providers don't know the exact cause of this disorder. They do know that it is linked with other infections.

In Italian children, Gianotti-Crosti syndrome is seen frequently with hepatitis B. But this link is rarely seen in the United States. Epstein-Barr virus (EBV, mononucleosis) is the virus most often associated with acrodermatitis.

Other associated viruses include:

  • Cytomegalovirus
  • Coxsackie viruses
  • Parainfluenza virus
  • Respiratory syncytial virus (RSV)
  • Some types of live virus vaccines
What are the symptoms of Gianotti-Crosti Syndrome?

Skin symptoms may include any of the following:

  • Rash or patch on the skin, usually on the arms and legs
  • Brownish-red or copper-colored patch that is firm and flat on top
  • String of bumps may appear in a line
  • Generally not itchy
  • Rash looks the same on both sides of the body
  • Rash may appear on the palms and soles, but not on the back, chest, or belly area (this is one of the ways it is identified, by the absence of the rash from the trunk of the body)

Other symptoms that may appear include:

  • Swollen abdomen
  • Swollen lymph nodes
  • Tender lymph nodes
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What are the current treatments for Gianotti-Crosti Syndrome?

The disorder itself is not treated. Infections linked with this condition, such as hepatitis B and Epstein-Barr, are treated. Cortisone creams and oral antihistamines may help with itching and irritation.

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What is the outlook (prognosis) for Gianotti-Crosti Syndrome?

The rash usually disappears on its own in about 3 to 8 weeks without treatment or complication. Associated conditions must be watched carefully.

What are the possible complications of Gianotti-Crosti Syndrome?

Complications occur as a result of associated conditions, rather than as a result of the rash.

When should I contact a medical professional for Gianotti-Crosti Syndrome?

Call your provider if your child has signs of this condition.

Gianotti-Crosti syndrome on the leg
Infectious mononucleosis
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What are the Latest Advances for Gianotti-Crosti Syndrome?
Transient symptomatic zinc deficiency in an exclusively breastfed infant.
Summary: Transient symptomatic zinc deficiency in an exclusively breastfed infant.
Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab
Summary: Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab
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Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition.
Summary: Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition.
Who are the sources who wrote this article ?

Published Date: April 14, 2021
Published By: Elika Hoss, MD, Senior Associate Consultant, Mayo Clinic, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Bender NR, Chiu YE. Eczematous disorders. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 674.

Gelmetti C. Gianotti-Crosti syndrome. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 91.