Glioblastoma
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Glioblastoma Overview

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Learn About Glioblastoma

View Main Condition: Brain Tumor

What is the definition of Glioblastoma?
Glioblastoma is the most aggressive type of brain cancer. Glioblastoma develops from glial cells, which are specialized cells that surround and support neurons (nerve cells) in the brain.  Glioblastomas are classified as malignant Grade 4 tumors, meaning that they are rapidly reproducing and spreading.
What are the alternative names for Glioblastoma?
Glioblastoma may also be referred to as glioblastoma multiforme or GBM. 
What are the causes of Glioblastoma?
The causes of glioblastoma are not well defined. However, glioblastoma can rarely occur in individuals who have had previous radiation therapy, or individuals who have genetic conditions including neurofibromatosis and Li-Fraumeni syndrome.
What are the symptoms of Glioblastoma?
The symptoms of glioblastomas vary by location of the tumor. Common symptoms of glioblastoma include increased pressure in the brain, headaches, fatigue, nausea, vomiting, memory issues, and seizures. 
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What are the current treatments for Glioblastoma?
There is currently no cure for glioblastoma. Treatment depends on several factors including the size and location of the tumor, as well as the patient's overall health. Most treatment plans are palliative and designed based on an individual patient's unique situation. In general, treatment for glioblastoma may include surgery, radiation therapy, and/or chemotherapy. Surgery to remove as much of the tumor as possible is generally the first step in treating glioblastoma. However, if a tumor is located near a sensitive area in the brain, surgery may not be possible at all. Radiation therapy often follows surgery for the treatment of glioma. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Chemotherapy involves the use of drugs, either taken orally or injected through a vein, to kill tumor cells. Chemotherapy is often used in combination with radiation therapy.
Who are the top Glioblastoma Local Doctors?
Elite in Glioblastoma
Dr. Andrew J. Tsung
Neurosurgery
Elite in Glioblastoma
Dr. Andrew J. Tsung
Neurosurgery
Referral may be required

OSF Illinois Neurological Institute - Neurosurgery

200 East Pennsylvania Avenue, 
Peoria, IL 
309-624-4000
Languages Spoken:
English
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Andrew Tsung is a Neurosurgery provider practicing medicine in Peoria, Illinois. Dr. Tsung is rated as an Elite provider by MediFind in the treatment of Glioblastoma. He is also highly rated in 47 other conditions, according to our data. His clinical expertise encompasses Glioblastoma, Astrocytoma, Glioma, Awake Craniotomy, and Gamma Knife Radiosurgery. Dr. Tsung is board certified in American Board Of Neurological Surgery.

Elite in Glioblastoma
Dr. Patrick Y. Wen
Neurology
Elite in Glioblastoma
Dr. Patrick Y. Wen
Neurology
Referral may be required

Dana-Farber Cancer Institute, Center For Neuro-Oncology

450 Brookline Avenue, 
Boston, MA 
617-632-2166
Languages Spoken:
English
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Offers Telehealth

Patrick Wen is a Neurologist practicing medicine in Boston, Massachusetts. Dr. Wen is rated as an Elite provider by MediFind in the treatment of Glioblastoma. He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Glioblastoma, Astrocytoma, Glioma, and Brain Tumor. Dr. Wen is board certified in Neurology and Neuro-Oncology.

 
 
 
 
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Elite in Glioblastoma
Dr. David Peereboom
Oncology | Hematology Oncology
Elite in Glioblastoma
Dr. David Peereboom
Oncology | Hematology Oncology
Referral may be required

Cleveland Clinic Main Campus

10201 Carnegie Avenue, 
Cleveland, OH 
866-223-8100
Languages Spoken:
English
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Offers Telehealth

David Peereboom is an Oncologist and a Hematologist Oncology provider practicing medicine in Cleveland, Ohio. Dr. Peereboom is rated as an Elite provider by MediFind in the treatment of Glioblastoma. He is also highly rated in 27 other conditions, according to our data. His clinical expertise encompasses Brain Tumor, Glioma, Glioblastoma, Astrocytoma, and Bone Marrow Aspiration. Dr. Peereboom is board certified in United Council For Neurological Subspecialties, 2008.

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What is the outlook (prognosis) for Glioblastoma?
The prognosis for individuals with glioblastoma is poor. There is currently no cure for glioblastoma, and many people live less than a year after they're diagnosed. Individuals who've had a portion of their tumor removed, or individuals undergoing chemotherapy and radiation therapy are likely to experience longer survival. 
How do I prevent Glioblastoma?
There is no known way to prevent glioblastomas. However, if you develop any symptoms common to a glioblastoma, it is recommended to make an appointment with your doctor to be properly diagnosed.
What are the latest Glioblastoma Clinical Trials?
Phase II Glioblastoma Accelerated Biomarkers Learning Environment Trial (GABLE)
Phase II Glioblastoma Accelerated Biomarkers Learning Environment Trial (GABLE)
Enrollment Status: Recruiting
Publish Date: June 18, 2026
Intervention Type: Drug, Procedure, Other
Study Phase: Phase 2

Summary: This phase II trial studies whether different imaging techniques can provide additional and more accurate information than the usual approach for assessing the activity of tumors in patients with newly diagnosed glioblastoma. The usual approach for this currently is magnetic resonance imaging (MRI). This study is trying to learn more about the meaning of changes in MRI scans after treatment, as wh...

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An Investigator-Initiated Clinical Trial to Evaluate the Safety, Tolerability, Dosimetry, and Preliminary Efficacy of [177Lu]Lu-DOTA-EB-RGD2 in Patients With Recurrent High-grade Glioma
An Investigator-Initiated Clinical Trial to Evaluate the Safety, Tolerability, Dosimetry, and Preliminary Efficacy of [177Lu]Lu-DOTA-EB-RGD2 in Patients With Recurrent High-grade Glioma
Enrollment Status: Recruiting
Publish Date: June 18, 2026
Intervention Type: Drug
Study Phase: Early Phase 1

Summary: This is an investigator-initiated, Phase I clinical trial. It aims to evaluate the safety, tolerability, dosimetry, and preliminary anti-tumor activity of a novel radiopharmaceutical, \[177Lu\]Lu-DOTA-EB-RGD2, in patients with recurrent high-grade gliomas. Participants will receive the drug either via intravenous infusion or directly into the tumor cavity through a pre-implanted Ommaya reservoir (...

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What are some Advocacy Organizations?
keep-punching-brain-cancer

Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.