Learn About Glioblastoma

View Main Condition: Brain Tumor

What is the definition of Glioblastoma?
Glioblastoma is the most aggressive type of brain cancer. Glioblastoma develops from glial cells, which are specialized cells that surround and support neurons (nerve cells) in the brain.  Glioblastomas are classified as malignant Grade 4 tumors, meaning that they are rapidly reproducing and spreading.
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What are the alternative names for Glioblastoma?
Glioblastoma may also be referred to as glioblastoma multiforme or GBM.
What are the causes of Glioblastoma?
The causes of glioblastoma are not well defined. However, glioblastoma can rarely occur in individuals who have had previous radiation therapy, or individuals who have genetic conditions including neurofibromatosis and Li-Fraumeni syndrome.
What are the symptoms of Glioblastoma?
The symptoms of glioblastomas vary by location of the tumor. Common symptoms of glioblastoma include increased pressure in the brain, headaches, fatigue, nausea, vomiting, memory issues, and seizures.
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What are the current treatments for Glioblastoma?
There is currently no cure for glioblastoma. Treatment depends on several factors including the size and location of the tumor, as well as the patient's overall health. Most treatment plans are palliative and designed based on an individual patient's unique situation. In general, treatment for glioblastoma may include surgery, radiation therapy, and/or chemotherapy. Surgery to remove as much of the tumor as possible is generally the first step in treating glioblastoma. However, if a tumor is located near a sensitive area in the brain, surgery may not be possible at all. Radiation therapy often follows surgery for the treatment of glioma. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Chemotherapy involves the use of drugs, either taken orally or injected through a vein, to kill tumor cells. Chemotherapy is often used in combination with radiation therapy.
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What is the outlook (prognosis) for Glioblastoma?
The prognosis for individuals with glioblastoma is poor. There is currently no cure for glioblastoma, and many people live less than a year after they're diagnosed. Individuals who've had a portion of their tumor removed, or individuals undergoing chemotherapy and radiation therapy are likely to experience longer survival.
How do I prevent Glioblastoma?
There is no known way to prevent glioblastomas. However, if you develop any symptoms common to a glioblastoma, it is recommended to make an appointment with your doctor to be properly diagnosed.
What are the latest Glioblastoma Clinical Trials?
Phase I / II Adaptive Randomized Trial of Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme

Summary: The goal of this clinical research study is to learn if vorinostat when given with isotretinoin and temozolomide can help to control glioblastoma or gliosarcoma. The safety of these drug combinations will also be studied.

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The Safety and Efficacy Study of Autologous Tumor-infiltrating Lymphocyte (TILs) Therapy Combined With Conventional Chemotherapy for Patients With Advanced Stage of Glioblastoma Multiforme.

Summary: The study is to evaluate the safety and efficacy of tumor infiltrating lymphocyte (TIL) therapy for patients with maligant glioblastoma multiforme. Autologous TiLs should be given by intravenous infusion after 5 days of lymphodepletion treatment.

What are the Latest Advances for Glioblastoma?
A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma.
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial.
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Neuronavigation-Guided Transcortical-Transventricular Endoport-Assisted Endoscopic Resection for Thalamic Lesions: Preliminary Experience.
What are some Advocacy Organizations?

Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.