Glioblastoma
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Glioblastoma Overview

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Learn About Glioblastoma

View Main Condition: Brain Tumor

What is the definition of Glioblastoma?
Glioblastoma is the most aggressive type of brain cancer. Glioblastoma develops from glial cells, which are specialized cells that surround and support neurons (nerve cells) in the brain.  Glioblastomas are classified as malignant Grade 4 tumors, meaning that they are rapidly reproducing and spreading.
What are the alternative names for Glioblastoma?
Glioblastoma may also be referred to as glioblastoma multiforme or GBM. 
What are the causes of Glioblastoma?
The causes of glioblastoma are not well defined. However, glioblastoma can rarely occur in individuals who have had previous radiation therapy, or individuals who have genetic conditions including neurofibromatosis and Li-Fraumeni syndrome.
What are the symptoms of Glioblastoma?
The symptoms of glioblastomas vary by location of the tumor. Common symptoms of glioblastoma include increased pressure in the brain, headaches, fatigue, nausea, vomiting, memory issues, and seizures. 
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What are the current treatments for Glioblastoma?
There is currently no cure for glioblastoma. Treatment depends on several factors including the size and location of the tumor, as well as the patient's overall health. Most treatment plans are palliative and designed based on an individual patient's unique situation. In general, treatment for glioblastoma may include surgery, radiation therapy, and/or chemotherapy. Surgery to remove as much of the tumor as possible is generally the first step in treating glioblastoma. However, if a tumor is located near a sensitive area in the brain, surgery may not be possible at all. Radiation therapy often follows surgery for the treatment of glioma. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Chemotherapy involves the use of drugs, either taken orally or injected through a vein, to kill tumor cells. Chemotherapy is often used in combination with radiation therapy.
Who are the top Glioblastoma Local Doctors?
Elite in Glioblastoma
Dr. Andrew J. Tsung
Neurosurgery
Elite in Glioblastoma
Dr. Andrew J. Tsung
Neurosurgery

OSF Illinois Neurological Institute - Neurosurgery

200 East Pennsylvania Avenue, 
Peoria, IL 
309-624-4000
Languages Spoken:
English
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Andrew Tsung is a Neurosurgery provider practicing medicine in Peoria, Illinois. Dr. Tsung is rated as an Elite provider by MediFind in the treatment of Glioblastoma. He is also highly rated in 47 other conditions, according to our data. His clinical expertise encompasses Glioblastoma, Astrocytoma, Glioma, Awake Craniotomy, and Gamma Knife Radiosurgery. Dr. Tsung is board certified in American Board Of Neurological Surgery.

Elite in Glioblastoma
Dr. Patrick Y. Wen
Neurology
Elite in Glioblastoma
Dr. Patrick Y. Wen
Neurology

Dana-Farber Cancer Institute, Center For Neuro-Oncology

450 Brookline Avenue, 
Boston, MA 
617-632-2166
Languages Spoken:
English
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Offers Telehealth

Patrick Wen is a Neurologist practicing medicine in Boston, Massachusetts. Dr. Wen is rated as an Elite provider by MediFind in the treatment of Glioblastoma. He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Glioblastoma, Astrocytoma, Glioma, and Brain Tumor. Dr. Wen is board certified in Neurology and Neuro-Oncology.

 
 
 
 
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Elite in Glioblastoma
Dr. David Peereboom
Oncology | Hematology Oncology
Elite in Glioblastoma
Dr. David Peereboom
Oncology | Hematology Oncology

Cleveland Clinic Main Campus

10201 Carnegie Avenue, 
Cleveland, OH 
866-223-8100
Languages Spoken:
English
See accepted insurances
Offers Telehealth

David Peereboom is an Oncologist and a Hematologist Oncology provider practicing medicine in Cleveland, Ohio. Dr. Peereboom is rated as an Elite provider by MediFind in the treatment of Glioblastoma. He is also highly rated in 27 other conditions, according to our data. His clinical expertise encompasses Brain Tumor, Glioblastoma, Glioma, Astrocytoma, and Bone Marrow Aspiration. Dr. Peereboom is board certified in United Council For Neurological Subspecialties, 2008.

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What is the outlook (prognosis) for Glioblastoma?
The prognosis for individuals with glioblastoma is poor. There is currently no cure for glioblastoma, and many people live less than a year after they're diagnosed. Individuals who've had a portion of their tumor removed, or individuals undergoing chemotherapy and radiation therapy are likely to experience longer survival. 
How do I prevent Glioblastoma?
There is no known way to prevent glioblastomas. However, if you develop any symptoms common to a glioblastoma, it is recommended to make an appointment with your doctor to be properly diagnosed.
What are the latest Glioblastoma Clinical Trials?
A Global, Multicenter, Prospective, Controlled, Open-Label Pivotal Study of Iodofalan (131I) Solution for Injection (TLX101-Tx) Plus Lomustine Versus Lomustine Alone in Patients With Radiographically Confirmed Recurrent Glioblastoma at First Recurrence (IPAX BrIGHT [IPAX-3])
A Global, Multicenter, Prospective, Controlled, Open-Label Pivotal Study of Iodofalan (131I) Solution for Injection (TLX101-Tx) Plus Lomustine Versus Lomustine Alone in Patients With Radiographically Confirmed Recurrent Glioblastoma at First Recurrence (IPAX BrIGHT [IPAX-3])
Enrollment Status: Recruiting
Publish Date: April 16, 2026
Intervention Type: Combination product, Radiation
Study Phase: Phase 3

Summary: This global clinical trial which evaluates the efficacy and safety of TLX101-Tx, an investigational radiopharmaceutical therapy, in combination with lomustine versus lomustine alone in adult patients with first recurrence of glioblastoma. TLX101-Tx delivers targeted radiation to glioblastoma cells. The trial is conducted in two parts: Part 1 assesses safety and radiation dosing; Part 2 is a random...

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Ultrasound Imaging in Brain Tumour Surgery With the Use of SonoClear® System Mimicking Brain Tissue.
Ultrasound Imaging in Brain Tumour Surgery With the Use of SonoClear® System Mimicking Brain Tissue.
Enrollment Status: Recruiting
Publish Date: April 16, 2026
Intervention Type: Device
Study Phase: Not Applicable

Summary: The objective of this clinical investigation is to assess the safety and performance of the SonoClear® System. Performance will be assessed by analysis of the contrast-to-noise ratio (CNR) and assessment of image quality by using the Surgeon Image Rating (SIR) Scale. This is a prospective, multi-centre single arm study where the performance of the SonoClear® System relative to routinely used acous...

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What are some Advocacy Organizations?
keep-punching-brain-cancer

Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.