Gliosarcoma
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Gliosarcoma Overview

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Learn About Gliosarcoma

View Main Condition: Brain Tumor

What is the definition of Gliosarcoma?
Gliosarcoma is a rare type of brain tumor that develops from glial cells, which are specialized cells that surround and support neurons (nerve cells). Unlike gliomas, gliosarcomas have a higher likelihood to spread to the lymph nodes, lungs, and liver. 
What are the causes of Gliosarcoma?
The cause of gliosarcomas is still unknown. However, gliosarcomas generally tend to be more common in adults than children. Men are also more likely to develop gliosarcomas than women.
What are the symptoms of Gliosarcoma?
The symptoms of gliosarcomas primarily depend on the tumor's location as well as how much the tumor has spread. Common symptoms include headaches, memory difficulties, fatigue, numbness, balance issues, and seizures. 
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What are the current treatments for Gliosarcoma?
Treatment for gliosarcoma may include surgery, radiation therapy, and/or chemotherapy. Surgery to remove as much of the tumor as possible is generally the first step in treating gliosarcoma. However, if a tumor is located near a sensitive area in the brain, surgery may not be possible at all. Radiation therapy often follows surgery for the treatment of gliosarcoma. Radiation therapy involves the use of high-energy beams, including X-rays or protons, to destroy tumor cells. Chemotherapy involves the use of drugs, either taken orally or injected through a vein, to kill tumor cells. Chemotherapy is often used in combination with radiation therapy.
Who are the top Gliosarcoma Local Doctors?
Henry Brem
Elite in Gliosarcoma
Dr. Henry Brem
Neurosurgery
Elite in Gliosarcoma
Dr. Henry Brem
Neurosurgery

Johns Hopkins Outpatient Center

601 North Caroline Street, Floor 5, Floor 5, 
Baltimore, MD 
410-955-6406
Languages Spoken:
English, Hebrew
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Henry Brem is a Neurosurgery provider in Baltimore, Maryland. Dr. Brem is rated as an Elite provider by MediFind in the treatment of Gliosarcoma. His top areas of expertise are Gliosarcoma, Glioma, Gliomatosis Cerebri, Osteotomy, and Posterior Fossa Decompression.

Jeffrey J. Olson
Elite in Gliosarcoma
Dr. Jeffrey J. Olson
Neurosurgery
Elite in Gliosarcoma
Dr. Jeffrey J. Olson
Neurosurgery

Emory Clinic At 1365 Clifton Road

1365 Clifton Road Northeast, BldgB, 
Atlanta, GA 
404-778-5770
Experience:
45+ years
Languages Spoken:
English
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Offers Telehealth

Jeffrey Olson is a Neurosurgery provider in Atlanta, Georgia. Dr. Olson has been practicing medicine for over 45 years and is rated as an Elite provider by MediFind in the treatment of Gliosarcoma. His top areas of expertise are Glioblastoma, Astrocytoma, Gliosarcoma, Awake Craniotomy, and Nerve Decompression.

 
 
 
 
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Patrick Y. Wen
Elite in Gliosarcoma
Dr. Patrick Y. Wen
Neurology
Elite in Gliosarcoma
Dr. Patrick Y. Wen
Neurology

Dana-Farber Cancer Institute, Center For Neuro-Oncology

450 Brookline Avenue, 
Boston, MA 
617-632-2166
Languages Spoken:
English
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Offers Telehealth

Patrick Wen is a Neurologist in Boston, Massachusetts. Dr. Wen is rated as an Elite provider by MediFind in the treatment of Gliosarcoma. His top areas of expertise are Glioblastoma, Astrocytoma, Glioma, and Brain Tumor.

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How do I prevent Gliosarcoma?
There is no known way to prevent gliosarcomas. However, if you develop any symptoms common to a gliosarcoma, it is recommended to make an appointment with your doctor to be properly diagnosed.
What are the latest Gliosarcoma Clinical Trials?
Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue (PRESERVE GBM)
Improving Understanding of Glioblastoma Through Preservation of Biologically Active Brain Tissue (PRESERVE GBM)
Enrollment Status: Recruiting
Publish Date: February 04, 2026
Intervention Type: Procedure

Summary: To collect and preserve glioblastoma tissue during standard of care tumor resection surgery and blood for future molecular and genetic testing. Tissue for research will be collected from three different regions within the same tumor to study how these regions differ in their structure, DNA, and RNA and also to compare the data obtained from this testing to imaging data found in the medical record....

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A Phase I Clinical Trial With a Window-of-Opportunity Component of Engineered NK Cells Containing Deleted TGF-ßR2 and NR3C1 in Recurrent Grade 4 Astrocytoma (Glioblastoma)
A Phase I Clinical Trial With a Window-of-Opportunity Component of Engineered NK Cells Containing Deleted TGF-ßR2 and NR3C1 in Recurrent Grade 4 Astrocytoma (Glioblastoma)
Who is this study for: Patients with recurrent glioblastoma
Enrollment Status: Recruiting
Publish Date: January 23, 2026
Intervention Type: Procedure, Biological
Study Drug: Cord Blood-derived Expanded Allogeneic Natural Killer Cells
Study Phase: Phase 1

Summary: This phase I trial is to find out the best dose, possible benefits and/or side effects of engineered natural killer (NK) cells containing deleted TGF-betaR2 and NR3C1 (cord blood \[CB\]-NK-TGF-betaR2-/NR3C1-) in treating patients with glioblastoma that has come back (recurrent). CB-NK-TGF-betaR2-/NR3C1- cells are genetically changed immune cells that may help to control the disease.

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What are some Advocacy Organizations?
keep-punching-brain-cancer

Keep Punching supports patients, healthcare providers, and researchers in their fight to prevent and eradicate brain cancer and minimize treatment-related side effects that may adversely impact function and comfort.