Learn About Glucocorticoid-Remediable Aldosteronism

What is the definition of Glucocorticoid-Remediable Aldosteronism?
Glucocorticoid-remediable aldosteronism is one of three types of familial hyperaldosteronism. Aldosterone is a hormone manufactured by the adrenal glands which helps the body retain water and sodium and excrete potassium. It is caused by a fusion of the CYP11B1 and CYP11B2 genes and is inherited in an autosomal dominant manner. These individuals are also at an increased risk for a certain type of stroke known as a hemorrhagic stroke. First-line therapy consists of a steroid such as prednisone, dexamethasone, or hydrocortisone. This will often correct the overproduction of aldosterone, lower the blood pressure, and correct the potassium levels.
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What are the alternative names for Glucocorticoid-Remediable Aldosteronism?
  • Glucocorticoid-remediable aldosteronism
  • Dexamethasone sensitive hypertension
  • Familial hyperaldosteronism type 1
  • Glucocorticoid sensitive hypertension
  • Hyperaldosteronism, familial type 1
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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

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