What is the definition of Glucocorticoid Resistance?

Glucocorticoid resistance is a rare genetic condition characterized by partial or generalized target tissue resistance to glucocorticoids. Glucocorticoids are steroid hormones produced by the adrenal cortex, which is an organ that sits on top of the kidneys.

What are the symptoms for Glucocorticoid Resistance?

Some individuals with glucocorticoid resistance may not have any symptoms. Symptoms of glucocorticoid resistance may include fatigue, high blood pressure, severe hyperandrogenism (increased steroid hormones that regulate the development of male characteristics), acne, seborrhea (inflamed skin), hair loss, increased body or facial hair, infertility, and infrequent or absent menstruation in women.

What are the current treatments for Glucocorticoid Resistance?

Some individuals with glucocorticoid resistance without symptoms do not need any treatment. Treatment for glucocorticoid resistance involves long-term use of high dose dexamethasone.