Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in the United States
The goal of this open-label, randomized trial is to assess the efficacy of doxycycline prophylaxis in reducing incidences of bacterial sexually transmitted infections (STIs) among adolescent and young adult females while also evaluating acceptability and antimicrobial resistance in order to inform public health policy.
• Age 13-29 years, inclusive;
• Self-reports GC, CT, and/or early syphilis diagnosis in the 12 months prior to screening;
• Self-reports condomless (oral, vaginal, and/or anal) intercourse at least once in the 30 days prior to screening
• Is at least 45 kilograms (99.2 pounds) in weight
• Fluent in English (able to read, speak, and understand English);
• Willing to undergo all required study procedures; and
• Willing to provide written informed consent to participate in the study.