Learn About Goodpasture Syndrome

What is the definition of Goodpasture Syndrome?

Anti-glomerular basement membrane diseases (anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney failure and lung disease.

Some forms of the disease involve just the lung or the kidney. Anti-GBM disease used to be known as Goodpasture syndrome.

Save information for later
Sign Up
What are the alternative names for Goodpasture Syndrome?

Goodpasture syndrome; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis - pulmonary hemorrhage

What are the causes of Goodpasture Syndrome?

Anti-GBM disease is an autoimmune disorder. It occurs when the immune system mistakenly attacks and destroys healthy body tissue. People with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomeruli) of the kidneys.

These substances are called antiglomerular basement membrane antibodies. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Antiglomerular basement membrane antibodies are antibodies against this membrane. They can damage the basement membrane, which can lead to kidney damage.

Sometimes, this disorder is triggered by a viral respiratory infection or by breathing in hydrocarbon solvents. In such cases, the immune system may attack organs or tissues because it mistakes them for these viruses or foreign chemicals.

The immune system's faulty response causes bleeding in the air sacs of the lungs and inflammation in the kidney's filtering units.

What are the symptoms of Goodpasture Syndrome?

Symptoms may occur very slowly over months or even years, but they often develop very quickly over days to weeks.

Loss of appetite, fatigue, and weakness are common early symptoms.

Lung symptoms may include:

  • Coughing up blood
  • Dry cough
  • Shortness of breath

Kidney and other symptoms include:

  • Bloody urine
  • Burning sensation when urinating
  • Nausea and vomiting
  • Pale skin
  • Swelling (edema) in any area of the body, especially in the legs
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Goodpasture Syndrome?

The main goal is to remove the harmful antibodies from the blood. Treatment may include:

  • Plasmapheresis, which removes harmful antibodies to help reduce inflammation in the kidneys and lungs.
  • Corticosteroid medicines (such as prednisone) and other drugs, which suppress or quiet the immune system.
  • Medicines such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), which help control blood pressure.
  • Dialysis, which may be done if kidney failure can no longer be treated.
  • A kidney transplant, which may be done when your kidneys no longer function.

You may be told to limit your intake of salt and fluids to control swelling. In some cases, a low-to-moderate protein diet may be recommended.

Who are the top Goodpasture Syndrome Local Doctors?
Elite
Elite
 
 
 
 
Learn about our expert tiers
Learn more
Elite
What are the support groups for Goodpasture Syndrome?

More information and support for people with anti-GBM disease and their families can be found at:

  • National Institute of Diabetes and Digestive and Kidney Diseases -- www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease
  • National Kidney Foundation -- www.kidney.org/atoz/content/goodpasture
  • National Organization for Rare Disorders -- rarediseases.org/rare-diseases/goodpasture-syndrome
What is the outlook (prognosis) for Goodpasture Syndrome?

An early diagnosis is very important. The outlook is much worse if the kidneys are already severely damaged when treatment begins. Lung damage can range from mild to severe.

Many people will need dialysis or a kidney transplant.

What are the possible complications of Goodpasture Syndrome?

Untreated, this condition can lead to any of the following:

  • Chronic kidney disease
  • End-stage kidney disease
  • Lung failure
  • Rapidly progressive glomerulonephritis
  • Severe pulmonary hemorrhage (lung bleeding)
When should I contact a medical professional for Goodpasture Syndrome?

Call for an appointment with your provider if you are producing less urine, or you have any other symptoms of anti-GBM disease.

How do I prevent Goodpasture Syndrome?

Never sniff glue or siphon gasoline with your mouth, which exposes the lungs to hydrocarbon solvents and can cause the disease.

Kidney blood supply
Glomerulus and nephron
What are the latest Goodpasture Syndrome Clinical Trials?
Comparison of ANCA and Anti-GBM Auto-antibodies Removal Kinetics Between Plasma Exchanges and Immunoadsorption in Patients With ANCA-associated Vasculitis or Anti-GBM Disease

Summary: Anti-neutrophil cytoplasmic antibodies (ANCA), directed against myeloperoxidase (MPO) and against proteinase 3 (PR3), have a pathogenic role during ANCA (AAV) vasculitis. Glomerular basement membrane (MBG) antibodies also have a direct pathogenic role in Goodpasture's syndrome and anti-MBG antibody glomerulonephritis (GN). In some patients, the severity of renal and / or pulmonary involvement just...

Match to trials
Find the right clinical trials for you in under a minute
Get started
What are the Latest Advances for Goodpasture Syndrome?
Anti-glomerular basement membrane disease: Treatment outcome of cyclophosphamide vs. rituximab induction therapy regimen.
Great prognosis of concurrent anti-GBM disease and IgA nephropathy in a young woman: A case report.
Tired of the same old research?
Check Latest Advances
Anti-glomerular Basement Membrane Disease: A Rare Case Report of Changing Clinical Phenotype and Atypicalities.
Who are the sources who wrote this article ?

Published Date: July 27, 2021
Published By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Schwarz MI, Matson S. Diffuse alveolar hemorrhage. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine.7th ed. Philadelphia, PA: Elsevier; 2022:chap 94.

Phelps RG, Turner AN. Anti-glomerular basement membrane disease and Goodpasture disease. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 24.

Radhakrishnan J, Appel GB, D'Agati VD. Secondary glomerular disease. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 32.