What is the definition of Granuloma Annulare?

Granuloma annulare (GA) is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring.

What are the alternative names for Granuloma Annulare?

Pseudorheumatoid nodule - subcutaneous granuloma annulare; GA

What are the causes for Granuloma Annulare?

GA most often affects children and young adults. It is slightly more common in females.

The condition is usually seen in otherwise healthy people. Sometimes, it may be associated with diabetes or thyroid disease. The exact cause of GA is unknown.

What are the symptoms for Granuloma Annulare?

GA usually causes no other symptoms, but the rash may be slightly itchy.

People usually notice a ring of small, firm bumps (papules) over the backs of the forearms, hands, or feet. Occasionally, they may find a number of rings.

In rare cases, GA appears as a firm nodule under the skin of the arms or legs. In some cases, the rash spreads all over the body.

What are the current treatments for Granuloma Annulare?

GA can resolve on its own. You may not need treatment for GA, except for cosmetic reasons. Very strong steroid creams or ointments are sometimes used to clear up the rash more quickly. Injections of steroids directly into the rings may also be effective. Some providers may choose to freeze the bumps with liquid nitrogen.

People with severe or widespread cases may need medicines that suppress the immune system. Laser and ultraviolet light therapy (phototherapy) may also help.

What is the outlook (prognosis) for Granuloma Annulare?

In most cases, GA disappears without treatment within 2 years. The rings can remain for many years. The appearance of new rings years later is not uncommon.

When should I contact a medical professional for Granuloma Annulare?

Call your provider if you notice ring-like bumps anywhere on your skin that do not go away within a few weeks.

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REFERENCES

Dinulos JGH. Cutaneous manifestations of internal disease. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 26.

Patterson JW. The granulomatous reaction pattern. In: Patterson JW, ed. Weedon's Skin Pathology. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 8.

  • Condition: Generalized Granuloma Annulare
  • Journal: Dermatology (Basel, Switzerland)
  • Treatment Used: Topical Corticosteroids as First-Line Treatment, Intralesional Triamcinolone Acetonide for Persistent Solitary Lesions
  • Number of Patients: 61
  • Published —
This study described disease characteristics, treatment outcome and associated diseases in patients treated for granuloma annulare, a chronic noninfectious granulomatous skin condition, with topical corticosteroids as the first-line treatment, and intralesional triamcinolone acetonide for persistent solitary lesions.
  • Condition: Subcutaneous Granuloma Annulare on Heel
  • Journal: The Journal of dermatology
  • Treatment Used: Avoiding Invasive Treatment
  • Number of Patients: 86
  • Published —
This case report discusses a 5-year-old Japanese girl with subcutaneous granuloma annulare (bumps) on the right heel.
Clinical Trial
  • Status: Active, not recruiting
  • Phase: Phase 1
  • Intervention Type: Drug
  • Participants: 15
  • Start Date: April 11, 2019
Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare