What is the definition of Grover's Disease?

Grover's disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months. Occasionally, this condition may persist for longer periods, or it may come and go over time. The exact cause is unknown; however, a number of factors may cause or worsen the condition including heat and sweating. While there is no cure for Grover's disease, there may be ways to manage the condition, such as avoidance of factors that worsen symptoms, moisturizers, and topical corticosteroids.

What are the alternative names for Grover's Disease?

  • TAD
  • Transient acantholytic dermatosis
  • Persistent acantholytic dermatosis

What are the causes for Grover's Disease?

The cause of Grover's disease is not well understood. There are certain factors that are suspected to lead to the development of Grover's disease or worsen symptoms including:
  • Heat and sweating
  • Sunlight
  • Exposure to ionizing radiation (example sun, microwaves, X-rays)
  • End-stage renal disease (kidney failure)
  • Prolonged bed rest
  • Organ transplantation

Some cases of Grover's disease have been associated with certain medications, including antiviral medications, such as ribavirin and biologic agents used for cancer therapy, such as anastrozole. Grover's disease has additionally been found in individuals who have other similar dermatological diseases, such as atopic dermatitis and contact dermatitis. 

What are the current treatments for Grover's Disease?

There is no cure for Grover's disease and treatment is usually based on a person's symptoms. Affected individuals are usually advised to avoid strenuous exercise and excessive sun exposure, as sweating and heat may induce more itchy spots. Initial treatment options include topical steroid creams such as hydrocortisone, anti-itch lotions containing menthol or camphor, and calcipotriol cream. For more severe cases, options include tetracycline, isotretinoin, antifungal pills such as itraconazole, PUVA phototherapy, and cortisone (steroid) injections. These treatments have important side effects and may not be necessary for mild cases.

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Clinical Trial
  • Status: Recruiting
  • Phase: N/A
  • Intervention Type: Device
  • Participants: 20
  • Start Date: September 1, 2020
Development & Preliminary Clinical Validation Blue Light Phototherapy Systems for T-Cell