Learn About Hallermann-Streiff Syndrome

What is the definition of Hallermann-Streiff Syndrome?
Hallermann-Streiff syndrome (HSS) is a rare condition with characteristic features that are present at birth and become more apparent over time. Signs and symptoms include an unusually shaped skull, distinctive facial features, thin skin and hair, and eye and dental abnormalities. Other features include poor vision, a small upper airway, and short stature. HSS is diagnosed based on a physical examination that identifies the specific signs and symptoms that have been described in this condition. The cause of HSS is unknown and is thought to be due to a random genetic change. HSS is not thought to be inherited in families. Because this condition is so rare, little is known about how HSS changes over time. Problems with airway management and premature aging have been reported. Most people with HSS have normal intelligence. Treatment for HSS is based on the specific symptoms and may involve multiple surgeries.
Save information for later
Sign Up
What are the alternative names for Hallermann-Streiff Syndrome?
  • Hallermann Streiff syndrome
  • HSS
  • Hallermann Streiff Francois syndrome
  • Francois dyscephalic syndrome
  • François dyscephalic syndrome
  • Oculomandibulofacial syndrome
What are the causes of Hallermann-Streiff Syndrome?
The genetic cause of Hallerman-Streiff syndrome has not been identified. It reportedly occurs randomly for unknown reasons (sporadically), most likely due to a new spontaneous (de novo) genetic alteration (mutation).
What are the symptoms of Hallermann-Streiff Syndrome?
The main features of Hallermann-Streiff syndrome include an unusually shaped skull and face, and abnormalities of the eyes, teeth, skin and hair. Many of the features are apparent at birth and vary from individual to individual. Some of the most common features include:
  • Short, broad head (brachycephaly) or small head (microcephaly)
  • Prominent forehead and/or sides of the skull (frontal bossing)
  • Small lower jaw (micrognathia)
  • Clouding of the lenses of the eyes at birth (congenital cataracts)
  • Unusually small eyes (microphthalmia)
  • Absent, malformed, or improperly aligned teeth
  • Sparse, thin hair (hypotrichosis)
  • Skin atrophy
  • Short stature
Because Hallermann-Streiff syndrome is so rare, not much is known about how this condition changes throughout life. Issues with premature aging and difficulty with airway managment have been reported. Most people with this condition have normal intelligence.
Not sure about your diagnosis?
Check Your Symptoms
Is Hallermann-Streiff Syndrome an inherited disorder?
Hallermann-Streiff syndrome does not appear to be inherited in families, although this remains unclear.
Who are the top Hallermann-Streiff Syndrome Local Doctors?
HN
Hironao Numabe
Distinguished
Highly rated in
5
conditions

Ochanomizu University

Shinjuku, JP 

Hironao Numabe is in Shinjuku, Japan. Numabe is rated as a Distinguished expert by MediFind in the treatment of Hallermann-Streiff Syndrome. They are also highly rated in 5 other conditions, according to our data. Their top areas of expertise are Hallermann-Streiff Syndrome, Thanatophoric Dysplasia, Chromosome 4q Deletion, and Cleft Hand Absent Tibia.

View Profile
HB
Herve Benateau
Distinguished
Highly rated in
6
conditions

Caen University Hospital

Caen, FR 

Herve Benateau is in Caen, France. Benateau is rated as a Distinguished expert by MediFind in the treatment of Hallermann-Streiff Syndrome. He is also highly rated in 6 other conditions, according to our data. His top areas of expertise are Hallermann-Streiff Syndrome, Brown-Sequard Syndrome, Progressive Hemifacial Atrophy, and Noma.

View Profile
 
 
 
 
Learn about our expert tiers
Learn more
BW
Bernd Wollnik
Distinguished
Highly rated in
54
conditions

University Medical Center Göttingen

Goettingen, NI, DE 

Bernd Wollnik is in Goettingen, Germany. Wollnik is rated as a Distinguished expert by MediFind in the treatment of Hallermann-Streiff Syndrome. He is also highly rated in 54 other conditions, according to our data. His top areas of expertise are Hallermann-Streiff Syndrome, Choanal Atresia, Microcephalic Osteodysplastic Primordial Dwarfism Type 2, and Microcephalic Osteodysplastic Primordial Dwarfism Type 1.

View Profile
View All Doctors
What are the latest Hallermann-Streiff Syndrome Clinical Trials?
Match to trials
Find the right clinical trials for you in under a minute
Get started
View All Clinical Trials
What are the Latest Advances for Hallermann-Streiff Syndrome?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.