Hand-Foot-Genital SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Hand-Foot-Genital Syndrome
Hand-foot-genital syndrome is a rare condition that affects the development of the hands and feet, the urinary tract, and the reproductive system. People with this condition have abnormally short thumbs and first (big) toes, small fifth fingers that curve inward (clinodactyly), and short feet. The bones in the wrists and ankles may be fused in people with this condition, or hardening of these bones may be delayed. The other bones in the arms and legs are normal.
Variants (also called mutations) in the HOXA13 gene cause hand-foot-genital syndrome. The HOXA13 gene provides instructions for producing a protein that plays an important role in development before birth. Specifically, this protein appears to be critical for the formation and development of the limbs (particularly the hands and feet), urinary tract, and reproductive system.
Hand-foot-genital syndrome is very rare; only a few families with the condition have been reported worldwide.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
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Pei-li Huang is a Reproductive Medicine provider practicing medicine in Reading, Massachusetts. Dr. Huang is rated as an Advanced provider by MediFind in the treatment of Hand-Foot-Genital Syndrome. She is also highly rated in 4 other conditions, according to our data. Her clinical expertise encompasses Hand-Foot-Genital Syndrome, Infertility, Sertoli Cell-Only Syndrome, and Tubal Disease.
Anupam Das practices practicing medicine in Kolkata, India. Mr. Das is rated as an Advanced expert by MediFind in the treatment of Hand-Foot-Genital Syndrome. He is also highly rated in 35 other conditions, according to our data. His clinical expertise encompasses Ringworm, Melasma, Type A Insulin Resistance Syndrome, Mastoidectomy, and Myringotomy.
Adult Genetics And Preventive Genomics Clinic
Aleksandar Rajkovic is a Medical Genetics specialist and an Obstetrics and Gynecologist practicing medicine in San Francisco, California. Dr. Rajkovic is rated as an Advanced provider by MediFind in the treatment of Hand-Foot-Genital Syndrome. He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Premature Ovarian Failure, Amenorrhea, 46XX Testicular Disorder of Sex Development, and Hand-Foot-Genital Syndrome. Dr. Rajkovic is board certified in American Board Of Medical Genetics And Genomics, Clinical Genetics And Genomics and American Board Of Obstetrics And Gynecology, Obstetrics & Gynecology. Dr. Rajkovic is currently accepting new patients.
Published Date: October 12, 2023
Published By: National Institutes of Health