Tumor-informed ctDNA Testing for Minimal Residual Disease Monitoring Following Curative-intent Treatment of Squamous Cell Carcinoma of the Head and Neck.
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Other
Study Type: Observational
SUMMARY
This is a single-center, non-interventional, observational study that evaluates the correlation of circulating tumor DNA (ctDNA) testing to cancer relapse for participants with squamous cell carcinomas (HNC) of the head and neck mucosa and skin after curative-intent primary radiation or surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Participants must have histologically or cytologically confirmed squamous cell carcinoma of the head and neck mucosa and skin.
• Participants must be age \>=18 years.
• Participants must be planning to receive curative-intent surgery or radiation-based treatment as part of standard of care treatment.
• Participants must have the ability to understand and the willingness to sign a written informed consent document.
Locations
United States
California
University of California, San Francisco
RECRUITING
San Francisco
Contact Information
Primary
Sonia Contreras Martinez
sonia.contrerasmartinez@ucsf.edu
415-514-6427
Time Frame
Start Date: 2024-10-09
Estimated Completion Date: 2029-12-30
Participants
Target number of participants: 250
Treatments
Cohort A: Non-investigational Radiation therapy
Participants will have tumor tissue collected at screening and blood samples (approximately 20ml x 3) will be obtained during non-investigational, standard of care radiation and after care for up to 2 years.
Cohort B: Non-investigational Surgery
Participants will have tumor tissue collected at screening and blood samples (approximately 20ml x 3) will be obtained during non-investigational, standard of care surgery and after care for up to 2 years.
Related Therapeutic Areas
Sponsors
Collaborators: Haystack Oncology, Inc.
Leads: University of California, San Francisco