Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle. Furthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis. The collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute a battery of tests allowing a precision diagnosis, then developed to all forms of presbycusis in order to study if the identification of abnormal functional modules can usefully guide the diagnosis and the early fitting.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

⁃ For all participants:

• Be over the age of 18,

• Be affiliated to a social security system,

• Have a good command of the French language (oral and written).

⁃ For the group of participants with anticipated presbycusis:

• Over the age of 40, having a hearing aid recipient or coming for a first hearing aid recipient

• Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid recipient or declare a progressive genetic birth defect

⁃ For healthy volunteers:

⁃ \- Have no known hearing loss.

Locations
Other Locations
France
CEntre de Recherche et d'Innovation en Audiologie Humaine
RECRUITING
Paris
Laboratoire de correction auditive
NOT_YET_RECRUITING
Paris
Contact Information
Primary
Celine Quinsac
celine.quinsac@pasteur.fr
+33 (0)1 76 53 50 29
Backup
Paul Avan, MD
paul.avan@uca.fr
+33 (0)1 76 53 50 94
Time Frame
Start Date: 2022-07-28
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 700
Treatments
Experimental: people over the age of 18 who agree to participate in the research.
They are either people who have a hearing loss about 20 years older than their age and wear a hearing aid (or come in for a hearing aid), or people over the age of 40 with normal hearing for their age.
Related Therapeutic Areas
Sponsors
Collaborators: Laboratoire de correction auditive, CEntre de Recherche et d'Innovation en Audiologie Humaine
Leads: Institut Pasteur

This content was sourced from clinicaltrials.gov