Investigation of Anatomical Correlates of Speech Discrimination

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY

Understanding speech is essential for good communication. Individuals with hearing loss and poor speech discrimination often have little success with hearing aids because amplifying sound improves audibility, but not clarity of the speech signal. The purpose of this study is to determine the relative importance of the sensory cells of the inner ear and auditory neurons on speech discrimination performance in quiet and in noise. This information may be used as a predictor of hearing aid benefit. The investigators expect to find decreased speech understanding ability resulting from both loss of sensory cells and the loss of auditory neurons.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: t
View:

• Normal hearing to moderate sensorineural hearing loss

• Sufficient English proficiency to complete speech discrimination testing in English

Locations
United States
Massachusetts
Steward St. Elizabeth's Medical Center
RECRUITING
Brighton
Time Frame
Start Date: 2013-01
Estimated Completion Date: 2026-08
Participants
Target number of participants: 1652
Treatments
low HIN difficulty- anesthetized
Subjects with normal OHC function and who will be undergoing an previously scheduled anesthetized procedure will be assigned into 2 groups based on their self-perceived HIN difficulty (high and low difficulty), and then undergo a test battery consisting of auditory threshold tests, objective HIN assays, OHC measurements, cognitive processing, and central auditory processing evaluations. Immediately after anesthetization, electrocochleography (ECochG) will be used to measure CAP amplitudes, which will be correlated with measurements obtained from unanesthetized subjects as described below. This aim will determine the optimal CAP recording method with the strongest correlation with HIN performance in humans
high HIN difficulty- anesthetized
Subjects with normal OHC function and who will be undergoing an previously scheduled anesthetized procedure will be assigned into 2 groups based on their self-perceived HIN difficulty (high and low difficulty), and then undergo a test battery consisting of auditory threshold tests, objective HIN assays, OHC measurements, cognitive processing, and central auditory processing evaluations. Immediately after anesthetization, electrocochleography (ECochG) will be used to measure CAP amplitudes, which will be correlated with measurements obtained from unanesthetized subjects as described below. This aim will determine the optimal CAP recording method with the strongest correlation with HIN performance in humans
Hearing Aid fitting: MAD
Microphone adaptive directionality (MAD) feature will be activated, the WDC set to linear, and the DNR minimized
Hearing Aid fitting: WDC
Wide dynamic compression (WDC) feature will be set to target levels, the MAD feature set to omnidirectional, and the DNR minimized.
Hearing Aid fitting: DNR
Digital noise reduction (DNR) set to maximum, MAD set to omnidirectional, and WDC set to linear
Hearing Aid fitting: Positive control
All hearing aid features enables
Hearing Aid fitting: Negative control
All hearing aid features disabled
Authors
Michael Dybka
Related Therapeutic Areas
Sponsors
Leads: Steward St. Elizabeth's Medical Center of Boston, Inc.

This content was sourced from clinicaltrials.gov