Radiological and Audiological Correlation in Otosclerosis: a Prospective Case-Control Study Evaluating Temporal Bone CT, Bone Mineral Density, and Hearing Loss

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational case-control study is to evaluate the relationship between temporal bone computed tomography (CT) findings, bone mineral density (BMD), and audiological parameters in adults diagnosed with otosclerosis. The main questions it aims to answer are: Is there a correlation between temporal bone CT density values and the severity of hearing loss in otosclerosis? Do bone mineral density and serum vitamin D levels differ between otosclerosis patients and individuals without otosclerosis? Researchers will compare patients diagnosed with otosclerosis to a control group without otosclerosis to determine if CT-based density variations are associated with disease severity and systemic bone metabolism markers. Participants who have already had a temporal bone CT scan as part of their routine clinical evaluation will undergo: Bone mineral density (BMD) assessment via dual-energy X-ray absorptiometry (DEXA) Serum vitamin D level measurement Audiological testing, including pure tone audiometry and speech discrimination tests This study aims to improve the diagnostic and prognostic understanding of otosclerosis by integrating imaging, metabolic, and audiological data.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults diagnosed with otosclerosis based on audiological and clinical assessment

• Patients with available high-resolution CT scans and audiological data

• Individuals who have undergone stapedectomy or stapedotomy surgery

• Availability of bone mineral density and serum vitamin D data

• Patients without otosclerosis but with temporal CT imaging for other indications

• No history of conductive or mixed hearing loss

• Availability of BMD and vitamin D data

Locations
Other Locations
Turkey
Hacettepe University Hospitals
RECRUITING
Ankara
Contact Information
Primary
İbrahim Emir Yeşil, MD
iemiryesil@gmail.com
+905019103056
Backup
Gamze Atay, Assos Prof
gamze.atay@hacettepe.edu.tr
+90 312 305 4224
Time Frame
Start Date: 2022-01-01
Estimated Completion Date: 2025-05-01
Participants
Target number of participants: 86
Treatments
Otosclerosis Group
Participants diagnosed with otosclerosis based on clinical and audiological criteria. These individuals have undergone or are planned for stapedectomy or stapedotomy surgery. High-resolution CT scans and bone metabolism markers will be analyzed to assess correlations with disease severity.
Control Group
Individuals without otosclerosis who have undergone temporal bone CT imaging for unrelated reasons. They have no history of conductive or mixed hearing loss. Their imaging and metabolic parameters will be compared with those of the otosclerosis patients to identify significant differences.
Sponsors
Leads: İbrahim Emir Yeşil

This content was sourced from clinicaltrials.gov

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