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A Longitudinal Cohort Study of Hearing and Brain Development in Children and Adolescents With Hearing Loss Across Different Hearing Management Pathways and in Normal-Hearing Controls

Status: Recruiting

Location: See location...

Study Type: Observational

SUMMARY

This bidirectional observational cohort study aims to establish a Hearing and Brain Development (HBD) cohort in children and adolescents with hearing loss across different hearing management pathways, including hearing aid fitting, cochlear implantation, auditory brainstem implantation, gene therapy, and follow-up without intervention, as well as in a normal-hearing control group. Participants will undergo longitudinal assessments of hearing, speech, language, neurodevelopment, and multimodal brain function.

Eligibility

Participation Requirements

Sex: All

Maximum Age: 18

Healthy Volunteers: t

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• Age no more than 18 years.

• For the HA/CI/ABI/GT/FU groups: behavioral or pure-tone hearing threshold \>=20 dB HL, or air-conduction ABR \>=35 dB nHL; For the normal-hearing control group: participants diagnosed as normal hearing by experienced physicians.

Locations

Other Locations

China

Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine

RECRUITING

Shanghai

Contact Information

Primary

Yun Li

liyuncmm@126.com

+86-21-53314064

Time Frame

Start Date: 2026-05-20

Estimated Completion Date: 2030-12-31

Participants

Target number of participants: 5000

Treatments

Participants suitable for unilateral or bilateral hearing aid(s) fitting, without any other intervention methods (cochlear implantation, gene therapy treatment, auditory brainstem implantation, etc.).

Participants suitable for unilateral or bilateral cochlear implantation, without gene therapy treatment or auditory brainstem implantation.

ABI

Participants suitable for unilateral or bilateral auditory brainstem implantation.

Participants suitable for gene therapy treatment.

Participants with hearing loss who do not receive any intervention.

NH Control

Participants with normal hearing who are enrolled as healthy controls.

Related Therapeutic Areas

Hearing Loss

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