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A Multi-Centre, Randomised Trial Assessing the Value of Computed Tomography Coronary Angiography Prior to Invasive Coronary Angiography in Patients With Previous Coronary Artery Bypass Grafts in Reducing Cardiac Events

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to evaluate whether a coronary computed tomography angiography (CTCA)-guided strategy can reduce the risk of death, heart attack, stroke, and hospital admissions in patients experiencing angina or myocardial infarction following coronary artery bypass graft (CABG) surgery. The main questions it aims to answer are: * Can CTCA reduce major adverse cardiovascular events compared to standard invasive coronary angiography? * Is CTCA a cost-effective and safer alternative that improves patient quality of life? Researchers will compare outcomes between patients receiving CTCA prior to angiography and those undergoing standard angiography alone to determine if CTCA improves clinical outcomes and procedural safety. Participants will: * Be randomly assigned to either CTCA-guided care or standard angiography * Undergo coronary imaging and follow-up assessments * Complete questionnaires on quality of life and healthcare resource use

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Aged ≥18

• Previous coronary artery bypass grafting (CABG)

• An indication for coronary angiography

‣ Angina

⁃ Ischaemia on perfusion imaging

⁃ Acute coronary syndrome

• Patients are able and willing to give their written informed consent

Locations
Other Locations
United Kingdom
St Bartholomew's Hospital
RECRUITING
London
Contact Information
Primary
Mervyn Andiapen
mervyn.andiapen@nhs.net
0203 765 8707
Backup
Matthew Kelham, MBBS, MD
m.kelham@nhs.net
Time Frame
Start Date: 2026-04-16
Estimated Completion Date: 2029-07-31
Participants
Target number of participants: 1000
Treatments
No_intervention: ICA only
Invasive coronary angiogram (ICA) performed only.
Active_comparator: CTCA with or without ICA
Computed Tomography Cardiac Angiography (CTCA) with or without invasive coronary angiogram (ICA)
Sponsors
Leads: Queen Mary University of London
Collaborators: National Institute for Health Research, United Kingdom

This content was sourced from clinicaltrials.gov