• Have Lp(a) ≥175 nanomoles per liter (nmol/L)

• Meet one of the following criteria:

‣ Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening

⁃ Are at risk for a first ASCVD event, defined as one or more of the following:

• Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event

∙ A high coronary artery calcium (CAC) score

∙ Reduced kidney function with diabetes

∙ Combination(s) of high risk factors