Heart Failure with Preserved Ejection Fraction (HFpEF) Overview

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Learn About Heart Failure with Preserved Ejection Fraction (HFpEF)

What is the definition of Heart Failure with Preserved Ejection Fraction (HFpEF)?
Heart failure with preserved ejection fraction is a syndrome wherein the left ventricle of the heart is unable to relax normally between each heartbeat. This leads to an increase in blood pressure in the left ventricle when blood fills it between each heartbeat. An ejection fraction measures how well the heart pumps blood. In heart failure with preserved ejection fraction, while there is heart failure the ejection fraction is normal.
What are the symptoms of Heart Failure with Preserved Ejection Fraction (HFpEF)?
Symptoms of heart failure with preserved ejection fraction include shortness of breath, especially when lying flat; chest discomfort; fatigue; exercise intolerance; abdominal swelling; and lower leg swelling.
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What are the current treatments for Heart Failure with Preserved Ejection Fraction (HFpEF)?
Treatment for heart failure with preserved ejection fraction includes treating high blood pressure with medications, diuretics, and cardiac revascularization.
Who are the top Heart Failure with Preserved Ejection Fraction (HFpEF) Local Doctors?
Dalane W. Kitzman
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Dalane W. Kitzman
Cardiology
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Dalane W. Kitzman
Cardiology

Wake Forest University Health Sciences

4618 Country Club Rd, 
Winston Salem, NC 
336-716-3926
Languages Spoken:
English
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Accepting New Patients

Dalane Kitzman is a Cardiologist in Winston Salem, North Carolina. Dr. Kitzman is rated as an Elite provider by MediFind in the treatment of Heart Failure with Preserved Ejection Fraction (HFpEF). His top areas of expertise are Heart Failure with Preserved Ejection Fraction (HFpEF), Heart Failure, Atherosclerosis, and Cardiomyopathy. Dr. Kitzman is currently accepting new patients.

Robert J. Mentz
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Robert J. Mentz
Cardiology | Advanced Heart Failure and Transplant Cardiology
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Robert J. Mentz
Cardiology | Advanced Heart Failure and Transplant Cardiology

Duke Health Integrated Practice Inc

2351 Erwin Rd, 
Durham, NC 
919-684-8111
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Robert Mentz is a Cardiologist and an Advanced Heart Failure and Transplant Cardiologist in Durham, North Carolina. Dr. Mentz is rated as an Elite provider by MediFind in the treatment of Heart Failure with Preserved Ejection Fraction (HFpEF). His top areas of expertise are Heart Failure, Heart Failure with Preserved Ejection Fraction (HFpEF), Low Blood Pressure, Heart Transplant, and Endoscopy. Dr. Mentz is currently accepting new patients.

 
 
 
 
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Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Sheldon E. Litwin
Cardiology | Advanced Heart Failure and Transplant Cardiology
Elite in Heart Failure with Preserved Ejection Fraction (HFpEF)
Dr. Sheldon E. Litwin
Cardiology | Advanced Heart Failure and Transplant Cardiology

University Medical Associates Of The Medical University Of South Carol

171 Ashley Ave, 
Charleston, SC 
843-792-1414
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Sheldon Litwin is a Cardiologist and an Advanced Heart Failure and Transplant Cardiologist in Charleston, South Carolina. Dr. Litwin is rated as an Elite provider by MediFind in the treatment of Heart Failure with Preserved Ejection Fraction (HFpEF). His top areas of expertise are Heart Failure with Preserved Ejection Fraction (HFpEF), Heart Failure, Cardiomyopathy, Gastric Bypass, and Cardiac Ablation. Dr. Litwin is currently accepting new patients.

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What are the latest Heart Failure with Preserved Ejection Fraction (HFpEF) Clinical Trials?
Phase 2, Multicentre, Randomised, Double-blind, Placebo-controlled Safety and Efficacy Study of CDR132L on Reverse Cardiac Remodelling in Participants With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Phase 2, Multicentre, Randomised, Double-blind, Placebo-controlled Safety and Efficacy Study of CDR132L on Reverse Cardiac Remodelling in Participants With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Enrollment Status: Recruiting
Publish Date: August 12, 2025
Intervention Type: Drug
Study Phase: Phase 2

Summary: This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by chance. The study will last for about 60 weeks.

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Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
Effects of Ziltivekimab Versus Placebo on Heart Failure Symptoms and Physical Function in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
Enrollment Status: Recruiting
Publish Date: August 12, 2025
Intervention Type: Drug
Study Phase: Phase 3

Summary: The study is being done to see if ziltivekimab can be used to treat participants living with heart failure and inflammation. Participants will either get ziltivekimab (active medicine) or placebo (inactive substance that looks like the study medicine but does not contain any medicine). The treatment participants get is decided by chance. Participant's chance of getting ziltivekimab or placebo is t...

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