• Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligrams per liter (mg/L) at screening (visit 1)

• Disease specific - cardiovascular:

• N-terminal-pro-brain natriuretic peptide (NT-proBNP) greater than or equal to 225 picograms per milliliter (pg/mL) (375 pg/mL for participants with atrial fibrillation/flutter) at screening

• Diagnosis of heart failure (New York heart association (NYHA) Class II-III)

• Left ventricular ejection fraction (LVEF) greater than 40 percent documented by echocardiography within 12 months prior to or at screening (visit 1). The LVEF must be documented in medical records and the most recent measurement must be used to determine eligibility with no interim event signalling potential deterioration in ejection fraction (example myocardial infarction (MI) or heart failure (HF) hospitalisation)

• Structural heart disease and/or functional heart disease documented by echocardiography within 12 months prior to or at screening (visit 1) showing at least one of the following:

‣ Left atrial (LA) volume index greater than 34 milliliter per square meter (mL/m\^2)

⁃ LA diameter greater than or equal to 3.8 centimeter (cm)

⁃ LA length greater than or equal to 5.0 cm

⁃ LA area greater than or equal to 20 square centimeter (cm\^2)

⁃ LA volume greater than or equal to 55 milliliter (mL)

⁃ Intraventricular septal thickness greater than or equal to 1.1 cm

⁃ Posterior wall thickness greater than or equal to 1.1 cm

⁃ LV mass index greater than or equal to 115 gram per square meter (g/m\^2) in men or greater than or equal to 95 g/m\^2 in women

• h) E/e' (mean septal and lateral) greater than or equal to 10 i) e' (mean septal and lateral) less than 9 centimeter per second (cm/s)

• No heart failure hospitalisations or urgent heart failure visits between screening and randomisation

• Able to perform the 6-minute walk test (6MWT) at screening with a minimum distance of 100 metres

• Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score lesser than 80 at screening