MAgnetic Resonance Non-contrast Assessment of Cardiac Microvascular Dysfunction in Patients With Heart Failure With PrEserveD Ejection Fraction (MAPPED)

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Heart failure with preserved ejection fraction (HFpEF) causes hospitalizations, premature mortality and high health care costs. This is also due to poor understanding of HFpEF pathogenesis and, thus, lack of specific therapies. Prompted by the recent demonstration that HFpEF clusters different clinical phenotypes, the investigators propose that these phenogroups are driven by distinct myocardial abnormalities. Cardiac Magnetic Resonance (CMR) can help filling this gap in knowledge: on top of providing gold standard measurements for myocardial volume and cellular mass, recent technical advantages mean that this test can assess and quantify left ventricular extracellular volume, fibrosis and microvascular function accurately and non-invasively. In HFpEF patients, the investigators aim at assessing 1) the coronary microvascular function impairment; 2) the myocardial fibrotic burden; - seeking to understand the disease in order to improve care and cardiovascular outcomes for these patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Age greater of or equal to 18 years at enrolment

• Able to provide written informed consent

• Diagnosis of HFpEF as defined by the 2016 ESC Guidelines (only for HFpEF group)

Locations
Other Locations
Italy
IRCCS Istituto Auxologico Italiano
RECRUITING
Milan
Contact Information
Primary
Camilla Torlasco
c.torlasco@auxologico.it
+390261911
Backup
Luca Grappiolo
luca.grappiolo@auxologico.it
+390261911
Time Frame
Start Date: 2019-03-01
Estimated Completion Date: 2024-12-30
Participants
Target number of participants: 60
Treatments
HFpEF
patients with HFpEF
healthy volunteers
healthy volunteers matched for age and sex
Sponsors
Leads: Istituto Auxologico Italiano

This content was sourced from clinicaltrials.gov