Development of Cardiovascular Innovation Research Technologies

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow us the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases. Our team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Age ≥ 18 years of age

• Provision of written informed consent

• If not healthy volunteer, must be diagnosed with cardiovascular disease

Locations
United States
Ohio
Cardiovascular Innovation Research Center
RECRUITING
Cleveland
Contact Information
Primary
CIRC Program Coordinator
circ@ccf.org
216 636-5373
Backup
CIRC Study Coordinator
chens7@ccf.org
Time Frame
Start Date: 2022-09-09
Estimated Completion Date: 2042-09-09
Participants
Target number of participants: 1000
Treatments
Normal
Normal volunteers \>=18 years older
Cardiovascular Disease Patient
\>=18years older with known prior cardiovascular disease
Sponsors
Leads: The Cleveland Clinic

This content was sourced from clinicaltrials.gov