Left Ventricular Reverse Remodeling Outcomes Evaluation in Patients With Aortic Regurgitation After Surgical Treatment

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age over 18 years

• Planned primary elective surgery for chronic aortic regurgitation

• Presence of functional mitral regurgitation

• End-diastolic volume of the left ventricle \>= 250 ml

Locations
Other Locations
Russian Federation
Petrovsky National Research Center of Surgery
RECRUITING
Moscow
Voronezh Regional Clinical Hospital No. 1
RECRUITING
Voronezh
Contact Information
Primary
Eduard Charchyan, professor
charchmed@yahoo.com
+79262174114
Backup
Andrei Bulynin
bandrew@inbox.ru
+79081339584
Time Frame
Start Date: 2024-05-09
Estimated Completion Date: 2030-05
Participants
Target number of participants: 120
Treatments
MR < 2 no MvR
Patients with functional mitral regurgitation grade 0-1, 1 and 1-2 without mitral valve repair (MvR)
MR >= 2 no MvR
Patients with mitral valve functional regurgitation of grade 2 and more severe without mitral valve repair
MR < 2 MvR
Patients with functional mitral regurgitation grade 0-1, 1 and 1-2, mitral valve repaired
MR >= 2 MvR
Patients with mitral valve functional regurgitation of grade 2 and more severe, mitral valve repaired
Sponsors
Leads: Petrovsky National Research Centre of Surgery
Collaborators: Voronezh regional clinical hospital #1

This content was sourced from clinicaltrials.gov