Feasibility and Safety of Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Status: Recruiting
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• LVEF \<35%
• Acute heart failure with low cardiac output syndrome or cardiogenic shock
Contact Information
Primary
Marek Sramko, MD, PhD
marek.sramko@ikem.cz
+420776246127
Time Frame
Start Date: 2026-04-04
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 12
Treatments
Active_comparator: Treated patients
Observational cohort of patients receiving 3-OHB
Related Therapeutic Areas
Sponsors
Leads: Institute for Clinical and Experimental Medicine