Hemimegalencephaly
Symptoms, Doctors, Treatments, Advances & More

Hemimegalencephaly Overview

Save information for later
Sign Up

Learn About Hemimegalencephaly

What is the definition of Hemimegalencephaly?
Hemimegalencephaly is a rare malformation involving one side of the brain. It may occur alone or in association with other syndromes such as Proteus syndrome, tuberous sclerosis, linear sebaceous nevus syndrome, neurofibromatosis, Sturge-Weber syndrome, or Klippel-Trenaunay syndrome. Children with this disorder may have a large, asymmetrical head accompanied by seizures, partial paralysis, and impaired cognitive development. The cause of Hemimegalencephaly is not fully understood, but involves a disturbance of cells early in development and likely involves genes involved in patterning and symmetry.
What are the alternative names for Hemimegalencephaly?
  • Hemimegalencephaly
  • Macrencephaly
  • Unilateral Megalencephaly
Who are the top Hemimegalencephaly Local Doctors?
Elite in Hemimegalencephaly
Dr. Gary Mathern
Neurosurgery
Elite in Hemimegalencephaly
Dr. Gary Mathern
Neurosurgery

Office

5767 W Century Blvd Ste 200, 
Los Angeles, CA 
310-825-9111
Languages Spoken:
English

Gary Mathern is a Neurosurgery provider practicing medicine in Los Angeles, California. Dr. Mathern is rated as an Elite provider by MediFind in the treatment of Hemimegalencephaly. He is also highly rated in 9 other conditions, according to our data. His clinical expertise encompasses Hemimegalencephaly, Increased Head Circumference, Cortical Dysplasia, and Epilepsy.

Elite in Hemimegalencephaly
Kenji Sugai
Elite in Hemimegalencephaly
Kenji Sugai
Tokyo, JP 

Kenji Sugai practices practicing medicine in Tokyo, Japan. Mr. Sugai is rated as an Elite expert by MediFind in the treatment of Hemimegalencephaly. He is also highly rated in 15 other conditions, according to our data. His clinical expertise encompasses Hemimegalencephaly, Epilepsy in Children, Increased Head Circumference, and Seizures.

 
 
 
 
Learn about our expert tiers
Learn More
Elite in Hemimegalencephaly
Dr. William B. Dobyns
Medical Genetics | Pediatrics | Pediatric Neurology
Elite in Hemimegalencephaly
Dr. William B. Dobyns
Medical Genetics | Pediatrics | Pediatric Neurology

Fairview Express Care

717 Delaware St Se, Suite 340, 
Minneapolis, MN 
612-672-7422
Experience:
48+ years
Languages Spoken:
English
See accepted insurances
Accepting New Patients

William Dobyns is a Medical Genetics specialist and a Pediatrics provider practicing medicine in Minneapolis, Minnesota. He has been practicing medicine for over 48 years. Dr. Dobyns is rated as an Elite provider by MediFind in the treatment of Hemimegalencephaly. He is also highly rated in 46 other conditions, according to our data. His clinical expertise encompasses Increased Head Circumference, Cerebellar Hypoplasia, Cortical Dysplasia, and Lissencephaly. Dr. Dobyns is currently accepting new patients.

View All Doctors
What are the latest Hemimegalencephaly Clinical Trials?
Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies
Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies
Enrollment Status: Recruiting
Publish Date: April 13, 2026
Intervention Type: Genetic

Summary: Brain somatic mutations affecting genes of the mTOR signaling pathway are a well-established cause of cortical malformations, including focal cortical dysplasia and hemimegalencephaly. Somatic mutations in SLC35A2 have been identified in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE), while activating somatic mutations in the SHH pathway are associa...

Match to trials
Find the right clinical trials for you in under a minute
Get started
View All Clinical Trials
Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center