Learn About Hemoglobin C Disease

What is the definition of Hemoglobin C Disease?

Hemoglobin C disease is a blood disorder passed down through families. It leads to a type of anemia, which occurs when red blood cells break down earlier than normal.

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What are the alternative names for Hemoglobin C Disease?

Clinical hemoglobin C

What are the causes of Hemoglobin C Disease?

Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by a problem with a gene called beta globin.

The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.

What are the symptoms of Hemoglobin C Disease?

Most people do not have symptoms. In some cases, jaundice may occur. Some people may develop gallstones that need to be treated.

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What are the current treatments for Hemoglobin C Disease?

In most cases, no treatment is needed. Folic acid supplements may help your body produce normal red blood cells and improve the symptoms of the anemia.

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What is the outlook (prognosis) for Hemoglobin C Disease?

People with hemoglobin C disease can expect to lead a normal life.

What are the possible complications of Hemoglobin C Disease?

Complications may include:

  • Anemia
  • Gallbladder disease
  • Enlargement of the spleen
When should I contact a medical professional for Hemoglobin C Disease?

Contact your health care provider if you have symptoms of hemoglobin C disease.

How do I prevent Hemoglobin C Disease?

You may want to seek genetic counseling if you are at high risk for the condition and are considering having a baby.

Blood cells
What are the latest Hemoglobin C Disease Clinical Trials?
The Longitudinal Relationship of Hydroxyurea Adherence Behavior to Health-related Quality of Life, Barriers to Adherence and Habit Formation in Patients With Sickle Cell Disease.

Summary: The primary objective of this study is to better understand factors contributing to variations in hydroxyurea (HU) adherence behavior in adolescents and young adults (AYA) with sickle cell disease (SCD). To meet this objective, the researchers will conduct a prospective cohort study to determine the longitudinal relationship between HU adherence and health-related quality of life (HRQOL) overtime ...

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An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease

Summary: The primary objective of this study is to evaluate a potential behavioral intervention (MED-Go app). To meet this objective, the researchers will conduct a pilot randomized controlled trial to test the feasibility and acceptability of MED-Go app in adolescents and young adults (AYA) with sickle cell disease (SCD). The long-term goal of this research is to promote medication adherence behavior and ...

What are the Latest Advances for Hemoglobin C Disease?
Investigating the safety and efficacy of hematopoietic and mesenchymal stem cell transplantation for treatment of T1DM: a systematic review and meta-analysis.
Clinical Effects of Sodium-Glucose Transporter Type 2 Inhibitors in Patients With Partial Lipodystrophy.
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Who are the sources who wrote this article ?

Published Date: January 25, 2022
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Howard J. Sickle cell disease and other hemoglobinopathies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 154.

Smith-Whitley K, Kwiatkowski JL. Hemoglobinopathies. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 489.

So JCC, Ma ESK. Hemoglobin and hemoglobinopathies. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. St Louis, MO: Elsevier; 2023:chap 77.

Wilson CS, Vergara-Lluri ME, Brynes RK. Evaluation of anemia, leukopenia, and thrombocytopenia. In: Jaffe ES, Arber DA, Campo E, Harris NL, Quintanilla-Martinez L, eds. Hematopathology. 2nd ed. Philadelphia, PA: Elsevier; 2017:chap 11.