Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury: Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery. Investigators will also evaluate the safety and impact of pulsatile flow on clinical outcomes compared to non-pulsatile flow during cardiopulmonary bypass.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:
• Able to provide informed consent
• Scheduled for elective cardiac surgery with cardiopulmonary bypass
Locations
United States
Colorado
University of Colorado Hospital
RECRUITING
Aurora
Contact Information
Primary
Nathan J Clendenen, MD,MS
nathan.clendenen@cuanschutz.edu
3037245000
Time Frame
Start Date: 2025-05-19
Estimated Completion Date: 2028-10
Participants
Target number of participants: 1100
Treatments
Active_comparator: Non-pulsatile blood flow
Non-pulsatile blood flow during cardiopulmonary bypass
Active_comparator: Pulsatile blood flow
Pulsatile blood flow during cardiopulmonary bypass
Related Therapeutic Areas
Sponsors
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Leads: University of Colorado, Denver