Learn About Thrombocytopenia
Thrombocytopenia means there is an abnormally low amount of platelets. Platelets are parts of the blood that help blood to clot. This condition is sometimes associated with abnormal bleeding.
Low platelet count - thrombocytopenia
Thrombocytopenia is often divided into 3 major causes of low platelets:
- Not enough platelets are made in the bone marrow
- Increased removal of platelets in the bloodstream
- Increased trapping of platelets in the spleen or liver
Your bone marrow may not make enough platelets if you have any of the following conditions:
- Aplastic anemia (disorder in which the bone marrow does not make enough blood cells)
- Cancer in the bone marrow, such as leukemia
- Cirrhosis (liver scarring)
- Folate deficiency
- Infections in the bone marrow (very rare)
- Myelodysplastic syndrome (bone marrow does not make enough blood cells or makes defective cells)
- Vitamin B12 deficiency
Use of certain medicines may also lead to a low production of platelets in the bone marrow. The most common example is chemotherapy treatment for cancer.
The following health situations cause a low number of platelets:
- Disorder in which the proteins that control blood clotting become over active, most often during a serious illness (disseminated intravascular coagulation - DIC)
- Drug-induced low platelet count
- Enlarged spleen
- Disorder in which the immune system destroys platelets (immune thrombocytopenic purpura - ITP)
- Disorder that causes blood clots to form in small blood vessels, causing a low platelet count (thrombotic thrombocytopenic purpura - TTP)
You may not have any symptoms. Or you may have general symptoms, such as:
- Bleeding in the mouth and gums
- Bruising
- Nosebleeds
- Rash
Other symptoms depend on the cause.
Treatment depends on the cause of the condition. In some cases, a transfusion of platelets may be required to stop or prevent bleeding.
Duke Hematology Clinic - Clinic 1E
Gowthami Arepally is a Hematologist in Durham, North Carolina. Dr. Arepally has been practicing medicine for over 36 years and is rated as an Elite provider by MediFind in the treatment of Thrombocytopenia. Her top areas of expertise are Thrombocytopenia, Adult Immune Thrombocytopenia, Sickle Cell Disease, and Immune Thrombocytopenic Purpura (ITP).
Lan-ping Xu practices in Beijing, China. Xu is rated as an Elite expert by MediFind in the treatment of Thrombocytopenia. Their top areas of expertise are Graft Versus Host Disease (GvHD), Thrombocytopenia, Leukemia, Bone Marrow Transplant, and Bone Graft.
Atrium Health Levine Cancer Institute
Ruben Mesa is a Hematologist and an Oncologist in Charlotte, North Carolina. Dr. Mesa is rated as an Elite provider by MediFind in the treatment of Thrombocytopenia. His top areas of expertise are Myelofibrosis, Polycythemia Vera, Myeloproliferative Neoplasms (MPN), Bone Marrow Transplant, and Splenectomy. Dr. Mesa is currently accepting new patients.
The outcome depends on the disorder causing the low platelet counts.
Severe bleeding (hemorrhage) is the main complication. Bleeding may occur in the brain or gastrointestinal tract.
Contact your provider if you experience unexplained bleeding or bruising.
Prevention depends on the specific cause.
Summary: This clinical trial evaluates the effects of hemoglobin threshold-specific packed red blood cell (PRBC) transfusions on quality of life and functional outcomes in patients who have undergone chemotherapy or an allogeneic hematopoietic stem cell transplant for a high-grade myeloid neoplasm, acute myeloid leukemia, or B acute lymphoblastic lymphoma/leukemia. Some types of chemotherapy and stem cell ...
Summary: This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count \<50,000/μL). Approximately 399 patients in total will be enrolled, randomized 2:1 to either pacritinib (approximately 266 patients) or to P/C therapy (approximately 133 patients) Cond...
Published Date: March 31, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Abrams CS. Thrombocytopenia. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 158.
Branchford BR, Samelson-Jones BJ, Flood VH. Platelet and blood vessel disorders. In: Kliegman RM, St. Geme JW, Blum NJ, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 533.
Warkentin TE. Thrombocytopenia caused by hypersplenism, platelet destruction, or surgery/hemodilution. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 130.
Zeller MP, Ning S, Arnold DM, Gabe C. Diseases of platelet number: immune thrombocytopenia, neonatal alloimmune thrombocytopenia, and posttransfusion purpura. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 129.