Effects of Nitric Oxide on Vascular Responsiveness and on Endothelial Cells During Hemolysis in Patients With Pre-operative Endothelial Dysfunction Undergoing Prolonged Cardiopulmonary Bypass.
This study is an ancillary (add-on) study to the clinical trial entitled Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction, which has Clinical Trials.gov identifier NCT02836899. NCT02836899 trial randomizes cardiac surgical patients to receive either Nitric Oxide (NO) or a placebo during and after cardiac surgery. This ancillary study aims to assess the effects of Nitric Oxide on vascular responsiveness and on endothelial function during hemolysis in patients with pre-operative endothelial dysfunction undergoing cardiac surgery requiring prolonged cardiopulmonary bypass.
• Eligible and randomized in the trial NCT02836899
• Provide written informed consent
• Age ≥ 18 years of age
• Elective cardiac or aortic surgery with CPB \>90 minutes
• Clinical evidence of endothelial dysfunction assessed by a specifically designed questionnaire