Shiga-like toxin producing E coli hemolytic-uremic syndrome (STEC-HUS) is a disorder that most often occurs when an infection in the digestive system produces toxic substances. These substances destroy red blood cells and cause kidney injury.

HUS; STEC-HUS; Hemolytic-uremic syndrome

Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E coli bacteria (Escherichia coli O157:H7). However, the condition has also been linked to other gastrointestinal infections, including shigella and salmonella. It has also been linked to non-gastrointestinal infections.

HUS is most common in children. It is the most common cause of acute kidney failure in children. Several large outbreaks have been linked to undercooked hamburger meat contaminated with E coli.

E coli can be transmitted through:

• Contact from one person to another
• Consuming uncooked food, such as milk products or beef

STEC-HUS is not to be confused with atypical HUS (aHUS) which is not infection-related. It is similar to another disease called thrombotic thrombocytopenic purpura (TTP).

STEC-HUS often begins with vomiting and diarrhea, which may be bloody. Within a week, the person may become weak and irritable. People with this condition may urinate less than normal. Urine output may almost stop.

Red blood cell destruction leads to symptoms of anemia.

Early symptoms:

• Blood in the stools
• Irritability
• Fever
• Lethargy
• Vomiting and diarrhea
• Weakness

Later symptoms:

• Bruising
• Decreased consciousness
• Low urine output
• No urine output
• Pallor
• Seizures -- rare
• Skin rash that looks like fine red spots (petechiae)

Treatment may involve:

• Dialysis
• Medicines, such as corticosteroids
• Management of fluids and electrolytes
• Transfusions of packed red blood cells and platelets

This is a serious illness in both children and adults, and it can cause death. With proper treatment, more than half of people will recover. The outcome is better in children than adults.

Complications may include:

• Blood clotting problems
• Hemolytic anemia
• Kidney failure
• Hypertension leading to seizures, irritability, and other nervous system problems
• Too few platelets (thrombocytopenia)
• Uremia

Contact your provider if you develop symptoms of HUS. Emergency symptoms include:

• Blood in the stool
• No urination
• Reduced alertness (consciousness)

Contact your provider if you have had an episode of HUS and your urine output decreases, or you develop other new symptoms.

You can prevent the known cause, E coli, by cooking hamburger and other meats well. You should also avoid contact with unclean water and follow proper hand washing methods.

Published Date: March 31, 2024
Published By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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George G, Friedman KD. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndromes. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 132.

Mele C, Noris M, Remuzzi G. Hemolytic uremic syndrome. In: Ronco C, Bellomo R, Kellum JA, Ricci Z, eds. Critical Care Nephrology. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 50.