Shiga-like toxin producing E coli hemolytic-uremic syndrome (STEC-HUS) is a disorder that most often occurs when an infection in the digestive system produces toxic substances. These substances destroy red blood cells and cause kidney injury.
HUS; STEC-HUS; Hemolytic-uremic syndrome
Hemolytic-uremic syndrome (HUS) often occurs after a gastrointestinal infection with E coli bacteria (Escherichia coli O157:H7). However, the condition has also been linked to other gastrointestinal infections, including shigella and salmonella. It has also been linked to nongastrointestinal infections.
HUS is most common in children. It is the most common cause of acute kidney failure in children. Several large outbreaks have been linked to undercooked hamburger meat contaminated with E coli.
E coli can be transmitted through:
STEC-HUS is not to be confused with atypical HUS (aHUS) which is not infection-related. It is similar to another disease called thrombotic thrombocytopenic purpura (TTP).
STEC-HUS often begins with vomiting and diarrhea, which may be bloody. Within a week, the person may become weak and irritable. People with this condition may urinate less than normal. Urine output may almost stop.
Red blood cell destruction leads to symptoms of anemia.
Treatment may involve:
Spero Cataland is a Hematologist and a Hematologist Oncology doctor in Columbus, Ohio. Dr. Cataland has been practicing medicine for over 28 years and is rated as an Elite doctor by MediFind in the treatment of Hemolytic-Uremic Syndrome. He is also highly rated in 21 other conditions, according to our data. His top areas of expertise are D-Plus Hemolytic Uremic Syndrome, Hemolytic-Uremic Syndrome, Idiopathic Thrombocytopenic Purpura, and Purpura. He is licensed to treat patients in Ohio. Dr. Cataland is currently accepting new patients.
Gianluigi Ardissino is in Milan, Italy. Ardissino is rated as an Elite expert by MediFind in the treatment of Hemolytic-Uremic Syndrome. He is also highly rated in 12 other conditions, according to our data. His top areas of expertise are Hemolytic-Uremic Syndrome, D-Plus Hemolytic Uremic Syndrome, D-Minus Hemolytic Uremic Syndrome, and Thrombocytopenia.
Nicole Van De Kar is in Nijmegen, Netherlands. Van De Kar is rated as an Elite expert by MediFind in the treatment of Hemolytic-Uremic Syndrome. She is also highly rated in 13 other conditions, according to our data. Her top areas of expertise are D-Plus Hemolytic Uremic Syndrome, Hemolytic-Uremic Syndrome, D-Minus Hemolytic Uremic Syndrome, and Thrombocytopenia.
This is a serious illness in both children and adults, and it can cause death. With proper treatment, more than half of people will recover. The outcome is better in children than adults.
Complications may include:
Call your provider if you develop symptoms of HUS. Emergency symptoms include:
Call your provider if you have had an episode of HUS and your urine output decreases, or you develop other new symptoms.
You can prevent the known cause, E coli, by cooking hamburger and other meats well. You should also avoid contact with unclean water and follow proper hand washing methods.
Published Date : February 06, 2020
Published By : Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Alexander T, Licht C, Smoyer WE, Rosenblum ND. Diseases of the kidney and upper urinary tract in children. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap: 72.
Mele C, Noris M, Remuzzi G. Hemolytic uremic syndrome. In: Ronco C, Bellomo R, Kellum JA, Ricci Z, eds. Critical Care Nephrology. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 50.
Schneidewend R, Epperla N, Friedman KD. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndromes. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 134.