Hepatic Venoocclusive Disease with Immunodeficiency Symptoms, Doctors, Treatments, Advances & More

Learn About Hepatic Venoocclusive Disease with Immunodeficiency

What is the definition of Hepatic Venoocclusive Disease with Immunodeficiency?

Hepatic veno-occlusive disease with immunodeficiency (VODI) is a genetic disorder of the liver and immune system that appears before the age of 12 months in which the small veins of the liver become blocked.

Save information for later

What are the symptoms of Hepatic Venoocclusive Disease with Immunodeficiency?

Symptoms of veno-occlusive disease with immunodeficiency may include failure to thrive, abnormally small head, liver enlargement, fibrosis of the liver, recurrent bacterial and opportunistic infections, diarrhea, anemia, fluid in the abdomen (ascites), seizures, weakness on one side of the body (hemiparesis), leg paralysis (paraplegia), lung fibrosis, lung hemorrhage, recurrent pneumonia, recurrent ear infections, yellowing of the skin, mucous membranes, and whites of eyes (jaundice), low platelets, urinary retention, portal hypertension (high blood pressure), liver abnormalities, fibrosis of the heart, and liver failure. Most individuals with veno-occlusive disease with immunodeficiency do not survive childhood, while a few may survive into early adulthood.

Not sure about your diagnosis?

Check Your Symptoms

What are the current treatments for Hepatic Venoocclusive Disease with Immunodeficiency?

Treatment for veno-occlusive disease with immunodeficiency include intravenous immunoglobulin (IVIG), pneumocystis jeroveci (fungal infection) prophylaxis, treatment for infections, and liver transplantation in selected patients.

Who are the top Hepatic Venoocclusive Disease with Immunodeficiency Local Doctors?

Dr. Nancy A. Kernan

Pediatric Hematology Oncology | Pediatrics

Elite

Highly rated in

conditions

Pediatric Hematology Oncology
Pediatrics

Schwartz Research Building

1250 1st Avenue,

New York, NY

Nancy Kernan is a Pediatric Hematologist Oncology specialist and a Pediatrics expert in New York, New York. Kernan has been practicing medicine for over 45 years and is rated as an Elite expert by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. She is also highly rated in 10 other conditions, according to our data. Her top areas of expertise are Hepatic Venoocclusive Disease with Immunodeficiency, Graft Versus Host Disease (GvHD), Leukemia, Adult T-Cell Leukemia, and Bone Marrow Transplant. She is licensed to treat patients in New York. Kernan is currently accepting new patients.

Dr. Robert J. Soiffer

Hematology Oncology | Oncology

Elite

Highly rated in

conditions

Hematology Oncology
Oncology

Dana-Farber Cancer Institute

450 Brookline Ave,

Boston, MA

Robert Soiffer is a Hematologist Oncology specialist and an Oncologist in Boston, Massachusetts. Soiffer has been practicing medicine for over 40 years and is rated as an Elite expert by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. He is also highly rated in 27 other conditions, according to our data. His top areas of expertise are Graft Versus Host Disease (GvHD), Hepatic Venoocclusive Disease with Immunodeficiency, Chronic Graft Versus Host Disease (cGvHD), Acute Myeloid Leukemia (AML), and Bone Marrow Transplant. He is licensed to treat patients in Massachusetts. Soiffer is currently accepting new patients.

Learn about our expert tiers

Learn more

Dr. Stephan A. Grupp

Pediatric Hematology Oncology | Pediatrics | Emergency Medicine

Elite

Highly rated in

conditions

Pediatric Hematology Oncology
Pediatrics
Emergency Medicine

Children's Hospital Of Philadelphia

3401 Civic Center Blvd,

Philadelphia, PA

Stephan Grupp is a Pediatric Hematologist Oncology specialist and a Pediatrics expert in Philadelphia, Pennsylvania. Grupp has been practicing medicine for over 36 years and is rated as an Elite expert by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. He is also highly rated in 12 other conditions, according to our data. His top areas of expertise are Hepatic Venoocclusive Disease with Immunodeficiency, Acute Lymphoblastic Leukemia (ALL), Adult T-Cell Leukemia, Leukemia, and Bone Marrow Transplant. He is licensed to treat patients in Pennsylvania. Grupp is currently accepting new patients.

View All Doctors

What are the latest Hepatic Venoocclusive Disease with Immunodeficiency Clinical Trials?

Using Ultrasound Elastography to Predict Development of Sinusoidal Obstruction Syndrome

Who is this study for: Patients with Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Stem Cell Transplant Complications

Enrollment Status: Active, not recruiting

Publish Date: June 06, 2022

Intervention Type: Diagnostic Test

Study Phase: Phase 4

Summary: The long-term goal of our research is to accurately identify SOS patients who would benefit from defibrotide treatment using US SWE. The overall objective of this study is to validate SWE as an early diagnostic marker for SOS. Our central hypothesis is that SWE changes will precede clinical and conventional US diagnostic criteria for SOS. Our hypothesis has been formulated on the basis of our own ...

Match to trials

Find the right clinical trials for you in under a minute

Get started

Antithrombin-III for Patients With Hepatic Veno-occlusive Diseases Following Hematopoietic Stem Cell Transplantation

Who is this study for: Patients with hepatic veno-occlusive diseases following hematopoietic stem cell transplantation

Enrollment Status: Active, not recruiting

Publish Date: March 30, 2021

Intervention Type: Drug

Study Drug: Freeze-dried concentrated human antithrombin

Study Phase: Phase 2

Summary: To evaluate efficacy and safety of AT-III treatment in patients with hepatic veno-occlusive diseases following hematopoietic stem cell transplantation.

View All Clinical Trials

What are the Latest Advances for Hepatic Venoocclusive Disease with Immunodeficiency?