Hepatic Venoocclusive Disease with Immunodeficiency
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Hepatic Venoocclusive Disease with Immunodeficiency Overview

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Learn About Hepatic Venoocclusive Disease with Immunodeficiency

What is the definition of Hepatic Venoocclusive Disease with Immunodeficiency?
Hepatic veno-occlusive disease with immunodeficiency (VODI) is a genetic disorder of the liver and immune system that appears before the age of 12 months in which the small veins of the liver become blocked.
What are the symptoms of Hepatic Venoocclusive Disease with Immunodeficiency?
Symptoms of veno-occlusive disease with immunodeficiency may include failure to thrive, abnormally small head, liver enlargement, fibrosis of the liver, recurrent bacterial and opportunistic infections, diarrhea, anemia, fluid in the abdomen (ascites), seizures, weakness on one side of the body (hemiparesis), leg paralysis (paraplegia), lung fibrosis, lung hemorrhage, recurrent pneumonia, recurrent ear infections, yellowing of the skin, mucous membranes, and whites of eyes (jaundice), low platelets, urinary retention, portal hypertension (high blood pressure), liver abnormalities, fibrosis of the heart, and liver failure. Most individuals with veno-occlusive disease with immunodeficiency do not survive childhood, while a few may survive into early adulthood.
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What are the current treatments for Hepatic Venoocclusive Disease with Immunodeficiency?
Treatment for veno-occlusive disease with immunodeficiency include intravenous immunoglobulin (IVIG), pneumocystis jeroveci (fungal infection) prophylaxis, treatment for infections, and liver transplantation in selected patients.
Who are the top Hepatic Venoocclusive Disease with Immunodeficiency Local Doctors?
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Hematology Oncology | Oncology | Hematology
Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Hematology Oncology | Oncology | Hematology

Dana-Farber Cancer Institute, Lipper Multiple Myeloma Center

450 Brookline Avenue, 
Boston, MA 
Languages Spoken:
English
Offers Telehealth

Paul Richardson is a Hematologist Oncology specialist and an Oncologist practicing medicine in Boston, Massachusetts. Dr. Richardson is rated as an Elite provider by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. He is also highly rated in 18 other conditions, according to our data. His clinical expertise encompasses Multiple Myeloma, Hepatic Venoocclusive Disease with Immunodeficiency, Relapsed Refractory Multiple Myeloma (RRMM), Bone Marrow Transplant, and Bone Graft. Dr. Richardson is board certified in Medical Oncology.

Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Elite in Hepatic Venoocclusive Disease with Immunodeficiency

Dana-Farber Cancer Institute

450 Brookline Ave, 
Boston, MA 
Languages Spoken:
English

Robert Soiffer is an Oncologist practicing medicine in Boston, Massachusetts. Dr. Soiffer is rated as an Elite provider by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. He is also highly rated in 25 other conditions, according to our data. His clinical expertise encompasses Graft Versus Host Disease (GvHD), Hepatic Venoocclusive Disease with Immunodeficiency, Chronic Graft Versus Host Disease (cGvHD), Bone Marrow Transplant, and Bone Graft.

 
 
 
 
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Elite in Hepatic Venoocclusive Disease with Immunodeficiency
Elite in Hepatic Venoocclusive Disease with Immunodeficiency

Dana-Farber Cancer Institute

450 Brookline Ave, 
Boston, MA 
Languages Spoken:
English

Joseph Antin is an Oncologist practicing medicine in Boston, Massachusetts. Dr. Antin is rated as an Elite provider by MediFind in the treatment of Hepatic Venoocclusive Disease with Immunodeficiency. He is also highly rated in 25 other conditions, according to our data. His clinical expertise encompasses Graft Versus Host Disease (GvHD), Hepatic Venoocclusive Disease with Immunodeficiency, Chronic Graft Versus Host Disease (cGvHD), Bone Marrow Transplant, and Bone Marrow Aspiration.

What are the latest Hepatic Venoocclusive Disease with Immunodeficiency Clinical Trials?
A Phase II Intrapatient Open-Label Dose Escalation Trial of Defibrotide in Hematopoietic Cell Transplantation (HCT) Recipients With Sinusoidal Obstructive Syndrome (SOS) Post-HCT Associated With Either Renal and/or Pulmonary Dysfunction With Either Refractory or Progressive Disease Following Defibrotide Therapy

Summary: This research study is being done to determine the safety and tolerability of increasing doses of defibrotide within a single patient with sinusoidal obstructive syndrome (SOS)/veno-occlusive disease (VOD) after hematopoietic cell transplantation (HCT) associated with either kidney and/or lung impairment that has not obtained a complete response (CR) or progressed in severity with standard doses o...

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Prospective Multi Center Study of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS)

Summary: This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the HCT setting as a contributor of significant morbidity and mortality.

What are the Latest Advances for Hepatic Venoocclusive Disease with Immunodeficiency?