Ultrasound Measurements of Hepatic Vasculatures and Hepatic Doppler Assessment of Healthy Children

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Flow dynamics in the liver is altered in different hepatobiliary and cardiac pathologies, causing changes in hepatic vasculatures sizes and flow pattern changes which can be assessed by ultrasound (USG) study. Before one can use these measurements and observations to diagnose pathologies, a clear grasp of normality is crucial. In the field of pediatrics, this is particularly challenging as the normal range of measurements may change with age, weight, height, gender and race of children. Taking hepatic veno-occlusive disease as an example, current literature is conflicting regarding whether sonographic findings show consistent association with the disease. Sonographic findings therefore now have limited role in contributing to the diagnosis. This may be related to the lack of a robust age corrected normal range of measurement for reference. Existing literature shows that the normal portal vein diameter varies with age, weight and height and possibly gender. Literature for normal measurements of hepatic vein and hepatic artery in children is lacking. In this study, the investigators aim to conduct a prospective, cross-section observational study to establish the normal measurements ranges of hepatic vein, hepatic artery and portal vein in healthy children in the investigators' locality. Flow patterns, including qualitative assessment and quantitative measurements of resistive index and flow velocities will also be assessed. These age corrected normal measurements will be very helpful in the diagnosis and follow-up of hepatobiliary and cardiac pathologies associated with alterations in dynamics of hepatic circulation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 day
Maximum Age: 18
Healthy Volunteers: t
View:

• Patient \< / = 18 years of age.

• No history of hepatobiliary nor cardiac pathology as checked with record in ePR. Verbal confirmation will be done with patient or parent / legal guardian.

• Attending USG study other than that of the hepatobiliary system. (ie. Patients attending for thyroid USG, urinary system USG, musculoskeletal system USG etc.)

Locations
Other Locations
Hong Kong Special Administrative Region
Hong Kong Children's Hospital
RECRUITING
Hong Kong
Contact Information
Primary
Pui Kwan Joyce Chan, MBChB
cpk706@ha.org.hk
+85296362929
Time Frame
Start Date: 2020-11-01
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 300
Sponsors
Leads: Hong Kong Children's Hospital

This content was sourced from clinicaltrials.gov