Hereditary Spastic Paraparesis
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Hereditary Spastic Paraparesis Overview

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Learn About Hereditary Spastic Paraparesis

What is the definition of Hereditary Spastic Paraparesis?
Hereditary spastic paraparesis is a term that refers to a group of genetic degenerative neurological disorders that affect the upper motor neurons, causing progressive weakness and spasticity of the legs. There are more than 80 different types of hereditary spastic paraparesis.
What are the symptoms of Hereditary Spastic Paraparesis?
Hereditary spastic paraparesis can be uncomplicated, complicated, or complex. Symptoms of hereditary spastic paraparesis depend on the subtype and usually appear in early childhood. Symptoms of hereditary spastic paraparesis include muscle weakness and spasticity in the legs; difficulty walking; toe drag; impaired vision; balance problems; seizures; cognitive impairment; peripheral neuropathy; deafness; knee, hip, back, and ankle pain; urinary urgency; difficulty swallowing; and speech difficulties.
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What are the current treatments for Hereditary Spastic Paraparesis?
Treatment for hereditary spastic paraparesis depends on the subtype and symptoms. Treatment for hereditary spastic paraparesis may include watchful waiting; exercise; physical therapy; muscle-relaxing medications, such as Lioresal, baclofen, or botulinum toxin; oxybutynin; and orthotics.
Who are the top Hereditary Spastic Paraparesis Local Doctors?
Elite in Hereditary Spastic Paraparesis
Marina Scarlato
Elite in Hereditary Spastic Paraparesis
Marina Scarlato
Referral may be required
Milan, IT 

Marina Scarlato practices practicing medicine in Milan, Italy. Ms. Scarlato is rated as an Elite expert by MediFind in the treatment of Hereditary Spastic Paraparesis. She is also highly rated in 7 other conditions, according to our data. Her clinical expertise encompasses Hereditary Spastic Paraparesis, Spastic Paraparesis, Spastic Paraplegia Type 7, and Spastic Paraplegia Type 2.

Elite in Hereditary Spastic Paraparesis
Maria T. Bassi
Elite in Hereditary Spastic Paraparesis
Maria T. Bassi
Referral may be required
Via D. L. Monza 20, Lecco, 
Bosisio Parini, IT 

Maria Bassi practices practicing medicine in Bosisio Parini, Italy. Ms. Bassi is rated as an Elite expert by MediFind in the treatment of Hereditary Spastic Paraparesis. She is also highly rated in 12 other conditions, according to our data. Her clinical expertise encompasses Hereditary Spastic Paraparesis, Spastic Paraparesis, Spastic Paraplegia Type 7, and Spastic Paraplegia Type 2.

 
 
 
 
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Elite in Hereditary Spastic Paraparesis
Francesco Nicita
Elite in Hereditary Spastic Paraparesis
Francesco Nicita
Referral may be required
Rome, IT 

Francesco Nicita practices practicing medicine in Rome, Italy. Mr. Nicita is rated as an Elite expert by MediFind in the treatment of Hereditary Spastic Paraparesis. He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Hereditary Spastic Paraparesis, Spastic Paraplegia Type 2, Spastic Paraplegia Type 7, CACH Syndrome, and Thrombectomy.

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What are the latest Hereditary Spastic Paraparesis Clinical Trials?
The Effect of Targeting the Plantaris Muscle-tendon Unit in Surgical Correction of Ankle Equinus in Children
The Effect of Targeting the Plantaris Muscle-tendon Unit in Surgical Correction of Ankle Equinus in Children
Enrollment Status: Recruiting
Publish Date: March 12, 2026
Intervention Type: Procedure
Study Phase: Not Applicable

Summary: Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk. If not treated, children with ankle equinus frequently experience reduced function and long-term foot problems, such as pain. Currently, treatment options include surgery or Botulinum toxin (BoNTA) injection into the large calf muscles ...

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Surgical Outcomes of Foot Deformities in Hereditary Spastic Paraplegia: A Prospective Cohort Study
Surgical Outcomes of Foot Deformities in Hereditary Spastic Paraplegia: A Prospective Cohort Study
Enrollment Status: Recruiting
Publish Date: April 20, 2025

Summary: Through a prospective cohort study, we aim to dynamically evaluate the long-term benefits and risks associated with surgical interventions for hereditary spastic paraparesis (HSP) accompanied by foot deformities. Our goal is to systematically summarize clinical experiences to guide practice and ultimately optimize patient outcomes. The core research objectives include elucidating: 1. the long-term...

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