Hereditary Spastic Paraparesis Overview

Save information for later
Sign Up

Learn About Hereditary Spastic Paraparesis

What is the definition of Hereditary Spastic Paraparesis?
Hereditary spastic paraparesis is a term that refers to a group of genetic degenerative neurological disorders that affect the upper motor neurons, causing progressive weakness and spasticity of the legs. There are more than 80 different types of hereditary spastic paraparesis.
What are the symptoms of Hereditary Spastic Paraparesis?
Hereditary spastic paraparesis can be uncomplicated, complicated, or complex. Symptoms of hereditary spastic paraparesis depend on the subtype and usually appear in early childhood. Symptoms of hereditary spastic paraparesis include muscle weakness and spasticity in the legs; difficulty walking; toe drag; impaired vision; balance problems; seizures; cognitive impairment; peripheral neuropathy; deafness; knee, hip, back, and ankle pain; urinary urgency; difficulty swallowing; and speech difficulties.
Not sure about your diagnosis?
Check Your Symptoms
What are the current treatments for Hereditary Spastic Paraparesis?
Treatment for hereditary spastic paraparesis depends on the subtype and symptoms. Treatment for hereditary spastic paraparesis may include watchful waiting; exercise; physical therapy; muscle-relaxing medications, such as Lioresal, baclofen, or botulinum toxin; oxybutynin; and orthotics.
Who are the top Hereditary Spastic Paraparesis Local Doctors?
Experienced in Hereditary Spastic Paraparesis
Dr. Jose M. Casanova
Neurology
Experienced in Hereditary Spastic Paraparesis
Dr. Jose M. Casanova
Neurology

Summa Physicians Inc

500 Portage Lakes Dr, Suite A, 
Coventry Township, OH 
 (6.0 mi)
234-571-9933
Languages Spoken:
English, Hindi, Italian, Mandarin, Spanish
See accepted insurances
Accepting New Patients

Jose Casanova is a Neurologist in Coventry Township, Ohio. Dr. Casanova and is rated as an Experienced provider by MediFind in the treatment of Hereditary Spastic Paraparesis. His top areas of expertise are Migraine, Hemiplegia, Seizures, and Epilepsy. Dr. Casanova is currently accepting new patients.

Distinguished in Hereditary Spastic Paraparesis
Dr. Keith Mckee
Neurology | Physiatry
Distinguished in Hereditary Spastic Paraparesis
Dr. Keith Mckee
Neurology | Physiatry

Cleveland Clinic

9500 Euclid Ave, 
Cleveland, OH 
 (29.6 mi)
216-444-2200
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Keith Mckee is a Neurologist and a Physiatrist in Cleveland, Ohio. Dr. Mckee and is rated as a Distinguished provider by MediFind in the treatment of Hereditary Spastic Paraparesis. His top areas of expertise are Spastic Paraplegia Type 2, Spastic Paraplegia Type 5A, Troyer Syndrome, and Spastic Paraplegia-Epilepsy-Intellectual Disability Syndrome. Dr. Mckee is currently accepting new patients.

 
 
 
 
Learn about our expert tiers
Learn More
Distinguished in Hereditary Spastic Paraparesis
Dr. Francois A. Bethoux
Physiatry | Neurology
Distinguished in Hereditary Spastic Paraparesis
Dr. Francois A. Bethoux
Physiatry | Neurology

Cleveland Clinic

9500 Euclid Ave, 
Cleveland, OH 
 (29.6 mi)
216-444-2200
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Francois Bethoux is a Physiatrist and a Neurologist in Cleveland, Ohio. Dr. Bethoux and is rated as a Distinguished provider by MediFind in the treatment of Hereditary Spastic Paraparesis. His top areas of expertise are Spasticity, Multiple Sclerosis (MS), Hemiplegia, and Spastic Paraplegia Type 7. Dr. Bethoux is currently accepting new patients.

View All Doctors
What are the latest Hereditary Spastic Paraparesis Clinical Trials?
Intrathecal Baclofen for the Management of Hereditary Spastic Paraparesis: a Prospective Cohort Study
Intrathecal Baclofen for the Management of Hereditary Spastic Paraparesis: a Prospective Cohort Study
Enrollment Status: Recruiting
Publish Date: February 26, 2025

Summary: The investigators conduct a prospective cohort study to explore the treatment effectiveness of continuous infusion of intrathecal baclofen (ITB) for hereditary spastic paraplegia (HSP) in China, delve into the optimal timing for starting treatment, and investigate the response differences among different subtypes. The ultimate goal is to provide clinical evidence and guidance for the application o...

Match to trials
Find the right clinical trials for you in under a minute
Get started
Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast
Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast
Enrollment Status: Recruiting
Publish Date: November 25, 2024
Intervention Type: Other
Study Phase: Not Applicable

Summary: Hereditary spastic paraparesis is a group of inherited neurological diseases. Only symptomatic treatments exist for the moment. The Modifspa study (cf citation) carried out by the team showed that patients perceived a feeling of effectiveness of physiotherapy on lower limb spasticity. The aim of the Walk-up study is to objectivize this feeling of efficacy on gait disorders in these patients. This ...

View All Clinical Trials