Evaluation of an Intensive Training Program for Patients with Hereditary Spastic Paraparesis SPG4/Spast

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Hereditary spastic paraparesis is a group of inherited neurological diseases. Only symptomatic treatments exist for the moment. The Modifspa study (cf citation) carried out by the team showed that patients perceived a feeling of effectiveness of physiotherapy on lower limb spasticity. The aim of the Walk-up study is to objectivize this feeling of efficacy on gait disorders in these patients. This is an interventional study using physical training. The study is prospective, open, randomized in 2 parallel groups, one of which is a control group. Analyses will be comparative between the 2 groups during the course of the study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient with molecular diagnosis of hereditary spastic paraparesis based on pathogenic variant of SPAST gene,

• Walking possible for 6 minutes without human assistance (one or more technical aids are authorized: e.g. cane, walker, orthoses),

• At least 1 physiotherapy session per week already in place.

• Understanding of the protocol

• Possibility of connecting to the Internet from home to access video material provided as part of the protocol.

Locations
Other Locations
France
ICM, Hôpital Pitié-Salpêtrière
RECRUITING
Paris
Contact Information
Primary
Pauline Lallemant, MD
pauline.lallemant@icm-institute.org
1. 57.27.46.69
Backup
Rania Hilab, CRA
rania.hilab@icm-institute.org
1. 57.27.46.91
Time Frame
Start Date: 2024-04-04
Estimated Completion Date: 2026-10
Participants
Target number of participants: 50
Treatments
Experimental: the reeducation group
The population included in the reeducation group will benefit, in addition to their usual physiotherapy care (at least 1 session per week), from :~* 1 group physiotherapy session per week at the ICM or by videoconference from home for 6 weeks~* 2 sessions per week at home with video support sent by e-mail for 6 weeks~These 3 additional video or group sessions will last 30 min. These sessions will be created and adjusted by a physiotherapist and a Physical and Rehabilitation Medicine doctor. They will include exercises such as :~* Stretching~* posture~* Muscle strengthening~* Proprioception~And will be performed in standing, sitting and lying positions.
No_intervention: The control group
usual physiotherapy care (at least 1 session per week)
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov