Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?
Status: Recruiting
Location: See location...
Intervention Type: Combination product, Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes. Hypothesis The addition of lactate to a meal improves postprandial lipemia and reduces lipid storage in ectopic tissues through delayed absorption and faster removal of circulating lipids from circulation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: t
View:
• 50+ years
• Written and oral consent
• HbA1c 39-47 mmol/L
Locations
Other Locations
Denmark
Aarhus University Hospital
RECRUITING
Aarhus
Contact Information
Primary
Natasa B Zubanovic, Medical Doctor
natasa.bz@clin.au.dk
004561698000
Backup
Esben Søndergaard, M.D, Associate Professor
esben.sondergaard@clin.au.dk
Time Frame
Start Date: 2024-08-22
Estimated Completion Date: 2026-01
Participants
Target number of participants: 25
Treatments
Placebo_comparator: Placebo pre-diabetes
Experimental: Lactate pre-diabetes
Active_comparator: Healthy
We will include 8 healthy, normal-weight individuals (BMI 20-25 kg/m2, age 50+ years) as a healthy control group, who will be studied twice following ingestion of a liquid test meal to determine the differences in meal fat partitioning between insulin-sensitive and insulin-resistant individuals and to determine the intraindividual variation in meal fat partitioning. Furthermore, the extra PET scans performed in the healthy individuals will be used for precise quantification of the radiation exposure with the PET method (dosimetry) and validation of the PET method.
Related Therapeutic Areas
Sponsors
Leads: University of Aarhus