SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era
SCOPE is an observational, prospective study of HIV-1 infected volunteers designed to provide a specimen bank of samples with carefully characterized clinical data. SCOPE specimens will be used to examine multiple questions involving virologic, immunologic, and host factors involved in HIV-1 infection, progression, non-progression, response to treatment, control of HIV-1 virus, and evolution of drug resistance.
⁃ SCOPE is currently recruiting HIV-1 infected subjects with any of the following criteria:
• Documented HIV viral load less than 2000 copies/ml WITHOUT taking antiretroviral therapy
• Undetectable HIV viral load with CD4 T-cells consistently less than 350 for the last 12 months while taking a stable antiretroviral regimen.
• Antiretroviral naive and planning to start an antiretroviral regimen - any CD4 or HIV viral load acceptable.
• Long-term Non Progressors: HIV-positive at least 10 years, no antiretroviral therapy for the past 10 years or more, any viral load acceptable, CD4-T cell count always above 500.