HIV-1 Subtype-specific Drug Resistance in Patients Failing Dolutegravir-based 1st, 2nd or 3rd Line Regimens: the International Epidemiological Databases to Evaluate AIDS (IeDEA)
Status: Recruiting
Location: See all (20) locations...
Study Type: Observational
SUMMARY
This is a prospective observational study enrolling People Living with HIV (PLHIV) who are on a Dolutegravir-based AntiRetroviral Treatment (ART) regimen and experiencing virologic failure. Virologic failure is defined as two consecutive viral load measurements of \>1000 copies/mL of blood. The main aim of the study is to identify the drug-resistance mutations in the viral genome that are associated with this failure. To achieve this goal, patients fulfilling the eligibility criteria will be invited for a single study visit for the collection of blood. The extracted HIV virus will be sequenced through whole genome sequencing methods to identify the drug-resistance mutations. The study is conducted in 15-20 countries within six regions of the IeDEA cohort (International epidemiology Databases to Evaluate AIDS).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 10
Healthy Volunteers: f
View:
• Adults aged 18 years or older and adolescents (10-17 years)
• On any DTG-based ART regimen
• Who develop virologic failure (VF) defined as a VL \>1000 copies/mL (single or confirmed measurement),
• and have signed the informed consent.
Locations
Other Locations
Argentina
Centro Medico Huesped
RECRUITING
Buenos Aires
Brazil
Instituto Nacional de Infectiologia Evandro Chagas - Fiocruz
RECRUITING
Rio De Janeiro
Burkina Faso
Hopital de Jour du Centre Hospitalier Universitaire (CHU Souro Sanou)
RECRUITING
Bobo-dioulasso
Cambodia
National Centre for HIV/AIDS, Dermatology and STDs (NCHADS)
RECRUITING
Phnom Penh
Cameroon
Regional Hospital Limbe
RECRUITING
Limbe
Hospital Jamot
RECRUITING
Yaoundé
Kenya
Moi University, AMPATH
RECRUITING
Eldoret
Malawi
Lighthouse clinic
RECRUITING
Lilongwe
Martin Preuss Centre
RECRUITING
Lilongwe
Mexico
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
RECRUITING
Mexico City
Republic of the Congo
Centre de Traitement Ambulatoire
RECRUITING
Brazzaville
Centre de Traitement Ambulatoire
RECRUITING
Pointe-noire
Rwanda
Research for Development, Einstein-Rwanda Research and Capacity Building Program
RECRUITING
Kigali
Thailand
HIV-NAT/Thai Red Cross AIDS Research Center (TRCARC)