Modulation of Sarcopenia in Older Adult Women by Green Tea Extract

Status: Recruiting
Location: See location...
Intervention Type: Other, Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Introduction: One of the consequences of aging is the decrease in physical performance which can affect the quality of life of older people. Although physical exercise is beneficial in improving this problem, older women do not seem to benefit as much as men. In this sense, the use of ergonomic aids by women could compensate for these issues. Thus, green tea has shown beneficial effects on physical performance in athletes through, among others, improving blood flow and vasodilation, mitochondrial respiration, calcium management, glucose and amino acid uptake, lipid oxidation, modulation of muscle damage, antioxidant effect, and anabolic and catabolic hormones, activation of the hypothalamic-pituitary-adrenal axis, etc. Therefore, the deterioration of physical performance and quality of life of green tea.

Objective: To analyze the effect of supplementation with 1 g/day green tea extract (500 mg of polyphenols) for 10 weeks on quality of life values, physical performance (grip strength, walking speed, and resistance), and health biomarkers (biochemical, hematological, and hormonal) in women over 60 years of age who follow a physical training program.

Methods: A total of 20 female volunteers between 60 and 73 years old (age: 65.9±4.58 years, BMI: 25.09±3.24 and body fat percentage: 32.54±6.39) who followed a physical activity adapted to their age and abilities are the members of this study. The volunteers were divided into two groups: placebo (CG; n = 10) and supplemented with 1 g/day of green tea (GI; n = 10). Different physical tests were performed (grip strength, walking speed and resistance) and the quality of life questionnaire (WHOQOL-BREF) was passed and health biomarkers (biochemical, hematological, and hormonal) were analyzed at the beginning (T1) and at the end of the 10 weeks of intervention (T2).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 60
Maximum Age: 80
Healthy Volunteers: t
View:

• Older adult women between 60 and 80 years old, with the ability to carry out a physical activity program adapted to their age and health condition.

Locations
Other Locations
Spain
Faculty of Health Sciences, University of Valladolid Soria Campus
RECRUITING
Soria
Contact Information
Primary
Diego Fernández Lázaro, Professor; PhD
diego.fernandez.lazaro@uva.es
+34658073375
Backup
César Ignacio Fernández Lázaro, Professor; PhD
fernandezlazaro@usal.es
658073375
Time Frame
Start Date: 2024-03-05
Estimated Completion Date: 2025-04-01
Participants
Target number of participants: 120
Treatments
Experimental: Green tea supplementation group
2 capsules for 10 consecutive weeks, distributed in a single daily oral intake with the main meal
Placebo_comparator: Placebo supplementation group
2 capsules for 10 consecutive weeks, distributed in a single daily oral intake with the main meal
Related Therapeutic Areas
Sponsors
Collaborators: Instituto de Neurociencia de Castillas y Leon, Sanidad de Castilla y León
Leads: University of Valladolid

This content was sourced from clinicaltrials.gov