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Condition

Hives

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Hives?

Hives are raised, often itchy, red bumps (welts) on the surface of the skin. They can be an allergic reaction to food or medicine. They can also appear without cause.

What are the alternative names for Hives?

Urticaria - hives; Wheals

What are the causes for Hives?

When you have an allergic reaction to a substance, your body releases histamine and other chemicals into the blood. This causes itching, swelling, and other symptoms. Hives are a common reaction. People with other allergies, such as hay fever, often get hives.

Angioedema is swelling of the deeper tissue that sometimes occurs with hives. Like hives, angioedema can occur on any part of the body. When it occurs around the mouth or throat, the symptoms can be severe, including airway blockage.

Many substances can trigger hives, including:

  • Animal dander (especially cats)
  • Insect bites
  • Medicines
  • Pollen
  • Shellfish, fish, nuts, eggs, milk, and other foods

Hives may also develop as a result of:

  • Emotional stress
  • Extreme cold or sun exposure
  • Excessive perspiration
  • Illness, including lupus, other autoimmune diseases, and leukemia
  • Infections such as mononucleosis
  • Exercise
  • Exposure to water

Often, the cause of hives is not known.

What are the symptoms for Hives?

Symptoms of hives may include any of the following:

  • Itching.
  • Swelling of the surface of the skin into red- or skin-colored welts (called wheals) with clearly defined edges.
  • Wheals may get bigger, spread, and join together to form larger areas of flat, raised skin.
  • Wheals often change shape, disappear, and reappear within minutes or hours. It is unusual for a wheal to last more than 48 hours.
  • Dermatographism, or skin writing, is a type of hives. It is caused by pressure on the skin and results in immediate hives in the area that has been pressed on or scratched.
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What are the current treatments for Hives?

Treatment may not be needed if the hives are mild. They may disappear on their own. To reduce itching and swelling:

  • Do not take hot baths or showers.
  • Do not wear tight-fitting clothing, which can irritate the area.
  • Your provider may suggest that you take an antihistamine such as diphenhydramine (Benadryl) or cetirizine (Zyrtec). Follow your provider's instructions or the package instructions about how to take the medicine.
  • Other oral prescription medicines may be needed, especially if the hives are chronic (long-lasting).

If your reaction is severe, especially if the swelling involves your throat, you may need an emergency shot of epinephrine (adrenaline) or steroids. Hives in the throat can block your airway, making it difficult to breathe.

What is the outlook (prognosis) for Hives?

Hives may be uncomfortable, but they are usually harmless and disappear on their own.

When the condition lasts longer than 6 weeks, it is called chronic hives. Usually no cause can be found. Most chronic hives resolve on their own in less than 1 year.

What are the possible complications for Hives?

Complications of hives may include:

  • Anaphylaxis (a life-threatening, whole-body allergic reaction that causes breathing difficulty)
  • Swelling in the throat can lead to life-threatening airway blockage

When should I contact a medical professional for Hives?

Call 911 or your local emergency number if you have:

  • Fainting
  • Shortness of breath
  • Tightness in your throat
  • Tongue or face swelling
  • Wheezing

Call your provider if the hives are severe, uncomfortable, and do not respond to self-care measures.

How do I prevent Hives?

To help prevent hives avoid exposure to substances that give you allergic reactions.

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REFERENCES

Habif TP. Urticaria, angioedema, and pruritus. In: Habif TP, ed. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 6th ed. Philadelphia, PA: Elsevier; 2016:chap 6.

James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Erythema and urticaria. In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseases of the Skin. 13th ed. Philadelphia, PA: Elsevier Saunders; 2020:chap 7.

Latest Research

Latest Advance
Study
  • Condition: Hereditary Angioedema
  • Journal: Journal of drugs in dermatology : JDD
  • Treatment Used: Lanadelumab
  • Number of Patients: 12
  • Published —
In this study, researchers evaluated the long-term outcomes of using lanadelumab to prevent acute attacks of edema in persons with hereditary angioedema.
Latest Advance
Study
  • Condition: Fabry Disease
  • Journal: International journal of molecular sciences
  • Treatment Used: Enzyme Replacement Therapy
  • Number of Patients: 0
  • Published —
The study researched Fabry disease.

Clinical Trials

Clinical Trial
Behavioral
  • Status: Not yet recruiting
  • Study Type: Behavioral
  • Participants: 80
  • Start Date: January 1, 2022
Rejuvenation of Aged Muscle Stem Cells Through Exercise
Clinical Trial
Other
  • Status: Recruiting
  • Participants: 300
  • Start Date: August 20, 2021
Opioid-Redox Study