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Comparative Efficacy of Standard-Dose Versus Updosed Cetirizine in Acute Urticaria: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn whether a higher dose of cetirizine works better than the standard dose to relieve symptoms of acute urticaria (hives) in adults. The study also aims to learn about the safety of taking a higher dose for a short period of time. The main questions the study aims to answer are: 1. Does the higher dose of cetirizine help people with acute urticaria improve faster than the standard dose? 2. What side effects do participants experience when taking the higher dose? Researchers will compare two groups: one group taking the standard dose of cetirizine (10 mg per day) and another group taking a higher dose (40 mg per day). This will help researchers understand which dose works better and whether the higher dose is safe. Participants will: Take the assigned study medication for 7 days Record their daily symptoms, including itch and hive severity Return for follow-up visits on Day 3, Day 7, and Week 6 Have blood tests to check liver and kidney function before and after treatment This study may help improve treatment options for people with acute urticaria and reduce the need for unnecessary steroid use.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:

• Adults aged 18 to 60 years

• Clinical diagnosis of acute urticaria made by a physician

• Onset of new wheals within the past 24 hours

• Able and willing to comply with study procedures, complete symptom diaries, and attend follow-up visits

• Provides written informed consent prior to participation

Locations
Other Locations
Thailand
University of Phayao Hospital
RECRUITING
Phayao
Contact Information
Primary
Wasuchon Chaichan, MD
wasuchon.ch@gmail.com
+6654466666
Backup
Chonlawat Chaichan, MSc
Chonlawat.chaichan@gmail.com
Time Frame
Start Date: 2025-11-15
Estimated Completion Date: 2026-10
Participants
Target number of participants: 140
Treatments
Active_comparator: Standard-dose cetirizine 10 mg orally once daily
Participants in this arm will receive standard-dose cetirizine at 10 mg once daily for 7 days. The medication will be provided in capsule form. Participants will record their daily urticaria symptoms and return for scheduled follow-up visits to assess symptom improvement and safety outcomes.
Experimental: Updosed Cetirizine 40 mg/day
Participants in this arm will receive high-dose cetirizine at 40 mg per day, taken as 20 mg twice daily for 7 days. The medication will be provided in capsule form. Participants will record their daily urticaria symptoms and return for scheduled follow-up visits to assess symptom improvement, the need for rescue medications, and any side effects.
Related Therapeutic Areas
Sponsors
Leads: University of Phayao

This content was sourced from clinicaltrials.gov

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