Howel-Evans Syndrome
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Howel-Evans Syndrome Overview

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Learn About Howel-Evans Syndrome

What is the definition of Howel-Evans Syndrome?
Tylosis with esophageal cancer (TOC) is an inherited condition that increases the risk for esophageal cancer. The symptoms of TOC include thickening of the skin on the palms and soles of the feet (palmoplantar keratoderma) and white lesions inside the mouth. People with TOC are at very high risk to develop esophageal cancer. The palmoplantar keratoderma usually occurs in childhood, and esophageal cancer usually occurs in adulthood. TOC is caused by a variant in the RHBDF2 gene and is inherited in an autosomal dominant pattern. Diagnosis is based on the symptoms, clinical exam, and family history. The diagnosis may be confirmed by the results of genetic testing.
What are the alternative names for Howel-Evans Syndrome?
  • Tylosis with esophageal cancer
  • Bennion-Patterson syndrome
  • Howel-Evans syndrome
  • Howell-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer
  • Keratosis palmoplantaris with esophageal cancer
  • Keratosis palmoplantaris-esophageal carcinoma syndrome
  • Palmoplantar hyperkeratosis-esophageal carcinoma syndrome
  • Palmoplantar keratoderma-esophageal carcinoma syndrome
  • TOC
  • Tylosis - oesophageal carcinoma
  • Tylosis-oesophageal carcinoma syndrome
Who are the top Howel-Evans Syndrome Local Doctors?
Advanced in Howel-Evans Syndrome
Dr. Kord S. Honda
Dermatology
Advanced in Howel-Evans Syndrome
Dr. Kord S. Honda
Dermatology
Referral may be required
Before you request

University Hospitals

11100 Euclid Ave, 
Cleveland, OH 
216-844-8200
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Kord Honda is a Dermatologist practicing medicine in Cleveland, Ohio. Dr. Honda is rated as an Advanced provider by MediFind in the treatment of Howel-Evans Syndrome. He is also highly rated in 79 other conditions, according to our data. His clinical expertise encompasses Melanoma, Erythroderma, Hereditary Mucoepithelial Dysplasia, and Stiff Skin Syndrome. Dr. Honda is currently accepting new patients.

Experienced in Howel-Evans Syndrome
Dr. Jennifer N. O'reilly
Internal Medicine
Experienced in Howel-Evans Syndrome
Dr. Jennifer N. O'reilly
Internal Medicine
Before you request

Bassett Health Center Norwich

55 Calvary Drive, 
Norwich, NY 
607-336-6362
Experience:
18+ years
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Jennifer O'reilly is a primary care provider, practicing in Internal Medicine in Norwich, New York. She has been practicing medicine for over 18 years. Dr. O'reilly is rated as an Experienced provider by MediFind in the treatment of Howel-Evans Syndrome. She is also highly rated in 13 other conditions, according to our data. Her clinical expertise encompasses Ringworm, Maturity Onset Diabetes of the Young, Hypertension, and Glucocorticoid-Remediable Aldosteronism. Dr. O'reilly is currently accepting new patients.

 
 
 
 
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Experienced in Howel-Evans Syndrome
Experienced in Howel-Evans Syndrome
Referral may be required
Before you request

Indian River Health Services Inc

3555 10th Ct, Suite 200a, 
Vero Beach, FL 
772-563-4673
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Jonathan Braue is a Dermatologist practicing medicine in Vero Beach, Florida. Dr. Braue is rated as an Experienced provider by MediFind in the treatment of Howel-Evans Syndrome. He is also highly rated in 56 other conditions, according to our data. His clinical expertise encompasses Sunburn, Actinic Keratosis, Warts, and Seborrheic Keratosis. Dr. Braue is board certified in American Board Of Dermatology, 2019. Dr. Braue is currently accepting new patients.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center