Howel-Evans Syndrome Overview

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Learn About Howel-Evans Syndrome

What is the definition of Howel-Evans Syndrome?
Tylosis with esophageal cancer (TOC) is an inherited condition that increases the risk for esophageal cancer. The symptoms of TOC include thickening of the skin on the palms and soles of the feet (palmoplantar keratoderma) and white lesions inside the mouth. People with TOC are at very high risk to develop esophageal cancer. The palmoplantar keratoderma usually occurs in childhood, and esophageal cancer usually occurs in adulthood. TOC is caused by a variant in the RHBDF2 gene and is inherited in an autosomal dominant pattern. Diagnosis is based on the symptoms, clinical exam, and family history. The diagnosis may be confirmed by the results of genetic testing.
What are the alternative names for Howel-Evans Syndrome?
  • Tylosis with esophageal cancer
  • Bennion-Patterson syndrome
  • Howel-Evans syndrome
  • Howell-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer
  • Keratosis palmoplantaris with esophageal cancer
  • Keratosis palmoplantaris-esophageal carcinoma syndrome
  • Palmoplantar hyperkeratosis-esophageal carcinoma syndrome
  • Palmoplantar keratoderma-esophageal carcinoma syndrome
  • TOC
  • Tylosis - oesophageal carcinoma
  • Tylosis-oesophageal carcinoma syndrome
Who are the top Howel-Evans Syndrome Local Doctors?
Advanced in Howel-Evans Syndrome
Dr. Kord S. Honda
Dermatology
Advanced in Howel-Evans Syndrome
Dr. Kord S. Honda
Dermatology

University Hospitals Medical Group Inc

11100 Euclid Ave, 
Cleveland, OH 
Languages Spoken:
English
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Accepting New Patients

Kord Honda is a Dermatologist in Cleveland, Ohio. Dr. Honda is rated as an Advanced provider by MediFind in the treatment of Howel-Evans Syndrome. His top areas of expertise are Melanoma, Erythroderma, Nakajo-Nishimura Syndrome, and Stiff Skin Syndrome. Dr. Honda is currently accepting new patients.

Christiane S. Querfeld
Experienced in Howel-Evans Syndrome
Dr. Christiane S. Querfeld
Dermatology
Experienced in Howel-Evans Syndrome
Dr. Christiane S. Querfeld
Dermatology

City Of Hope Medical Foundation

1601 Avocado Ave, 
Newport Beach, CA 
949-763-2204
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Christiane Querfeld is a Dermatologist in Newport Beach, California. Dr. Querfeld is rated as an Experienced provider by MediFind in the treatment of Howel-Evans Syndrome. Her top areas of expertise are Mycosis Fungoides, Cutaneous T-Cell Lymphoma (CTCL), T-Cell Lymphoma, and Sezary Syndrome.

 
 
 
 
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Experienced in Howel-Evans Syndrome
Dr. Kelli A. Hutchens
Dermatology
Experienced in Howel-Evans Syndrome
Dr. Kelli A. Hutchens
Dermatology

Forefront Dermatology Sc

801 York St, 
Manitowoc, WI 
920-683-5278
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Kelli Hutchens is a Dermatologist in Manitowoc, Wisconsin. Dr. Hutchens is rated as an Experienced provider by MediFind in the treatment of Howel-Evans Syndrome. Her top areas of expertise are Melanoma, Actinic Keratosis, Neurocutaneous Melanosis, and Seborrheic Keratosis. Dr. Hutchens is currently accepting new patients.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center