Learn About HTLV-1 Associated Myelopathy

What is the definition of HTLV-1 Associated Myelopathy?
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the nervous system that affects less than 2% of people with HTLV-1 infection. Signs and symptoms vary but may include slowly progressive weakness and spasticity of one or both legs, exaggerated reflexes, muscle contractions in the ankle, and lower back pain. Other features may include urinary incontinence and minor sensory changes, especially burning or prickling sensations and loss of vibration sense. The reason some people with HTLV-1 infection develop HAM/TSTP is not well understood.
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What are the alternative names for HTLV-1 Associated Myelopathy?
  • HTLV-1 associated myelopathy/tropical spastic paraparesis
  • HAM/TSP
  • Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis
  • Tropical spastic paraparesis (formerly)
Who are the top HTLV-1 Associated Myelopathy Local Doctors?
GT
Graham P. Taylor
Elite
Highly rated in
11
conditions

NIHR Imperial Biomedical Research Centre

GB 

Graham Taylor is in United Kingdom. Taylor is rated as an Elite expert by MediFind in the treatment of HTLV-1 Associated Myelopathy. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Spastic Paraparesis, HTLV-1 Associated Myelopathy, Adult T-Cell Leukemia, and Myelitis.

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YY
Yoshihisa Yamano
Elite
Highly rated in
8
conditions

Faculty Of Science

Department Of Rare Diseases Research, St. Marianna University School Of Medicine 
Kawasaki, JP 

Yoshihisa Yamano is in Kawasaki, Japan. Yamano is rated as an Elite expert by MediFind in the treatment of HTLV-1 Associated Myelopathy. They are also highly rated in 8 other conditions, according to our data. Their top areas of expertise are Spastic Paraparesis, HTLV-1 Associated Myelopathy, Relapsing Polychondritis, and Myelitis.

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Stephane Olindo
Elite
Highly rated in
13
conditions

Unité Neuro Vasculaire

Bordeaux, FR 

Stephane Olindo is in Bordeaux, France. Olindo is rated as an Elite expert by MediFind in the treatment of HTLV-1 Associated Myelopathy. She is also highly rated in 13 other conditions, according to our data. Her top areas of expertise are HTLV-1 Associated Myelopathy, Spastic Paraparesis, Myelitis, and Fibromuscular Dysplasia FMD.

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What are the latest HTLV-1 Associated Myelopathy Clinical Trials?
Immuno-Virological Evaluation of Human T Cell Leukemia Virus Type-1 Associated Myelopathy (HAM/TSP)
Status: Recruiting
Start Date: April 6, 1998
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Summary: Objective:~Human T-lymphotropic virus type-I-associated myelopathy / tropical spastic paraparesis (HAM/TSP) is a rare neurologic disorder that affects less than 5% of patients infected with the HTLV-I virus. The purpose of this protocol is to study the natural history of HAM/TSP by monitoring clinical progression of patients longitudinally. Additionally, we will attempt to define the virological a...
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Rituximab Therapy for the Patients With HTLV-1-associated Myelopathy
Who is this study for: Patients with Multiple System Atrophy
Status: Recruiting
Start Date: August 15, 2019
Intervention Type: Drug
Study Drugs: Rituximab
Phase: Phase 2
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Summary: Neuroprotective or anti-inflammatory strategies are invaluable in HTLV-1-associated myelopathy due to its rapid progression. We evaluated the efficacy of rituximab in patients with HTLV-1-associated myelopathy.
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Who are the sources who wrote this article ?

Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for HTLV-1 Associated Myelopathy?
HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread.
Journal: Viruses
Published: January 22, 2022
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Summary: HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread.
Human T-Cell Leukemia Virus Type 1 Envelope Protein: Post-Entry Roles in Viral Pathogenesis.
Journal: Viruses
Published: January 22, 2022
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Summary: Human T-Cell Leukemia Virus Type 1 Envelope Protein: Post-Entry Roles in Viral Pathogenesis.
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Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).
Journal: PloS one
Published: January 18, 2022
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Summary: Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).
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