Hydrocephalus and skeletal anomalies are signs and symptoms of different types of congenital abnormalities. Hydrocephalus is a build-up of fluid in the deep cavities of the brain. Skeletal anomalies are malformations of bones and depend on the type of congenital abnormality. Severe hydrocephalus and skeletal anomalies, in addition to kidney abnormalities, have been reported in a female child.

Symptoms of hydrocephalus depend on the age of onset. Symptoms of hydrocephalus in infants may include a rapid increase in head size, a bulging soft spot (fontanelle), vomiting, sleepiness, irritability, poor feeding, seizures, downward eye positioning, muscle weakness, and growth retardation. Symptoms of hydrocephalus in toddlers and older children may include blurred or double vision, downward eye positioning, enlargement of head, nausea, vomiting, urinary incontinence, lethargy, poor coordination and balance, lack of appetite, seizures, irritability, personality changes, decrease in school performance, and motor or speech delays. Symptoms of hydrocephalus in adolescents and young adults may include lethargy, headache, poor coordination and balance, urinary incontinence, blurred vision, and poor memory and focus. Symptoms of hydrocephalus in older adults may include urinary incontinence, memory loss, cognitive decline, poor coordination or balance, and shuffling when walking. There are many types of skeletal abnormalities. Skeletal abnormalities that may occur with hydrocephalus may include backward bending of the knees and curvature of the spine (scoliosis).

Treatment for hydrocephalus may include medications and surgery. Surgical treatment for hydrocephalus involves either the placement of a shunt designed to drain the excess fluid from the brain or endoscopic third ventriculostomy in which a hole is created in the bottom of one of the ventricles in the brain to allow all the fluid to drain out. Medications for hydrocephalus may include the use of anti-seizure medications for associated seizures. Children with hydrocephalus may additionally need special education and developmental therapy. Treatment for skeletal anomalies depends on the type and cause and may include surgical correction.