Unilateral Primary Aldosteronism, Mineralocorticoid Antagonists Versus Surgical Treatment - A Randomized Controlled Trial
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Drug, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a prospective randomized controlled trial where quality of life and the effectiveness of treatment will be evaluated in 80 patients with confirmed unilateral primary aldosteronism ,randomly assigned to be either treated surgically with unilateral adrenalectomy or to receive medical treatment with eplerenone.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Patients with confirmed unilateral PA
• Age 18-70 years
• Candidate for surgical treatment
• No contraindications for minimally invasive surgery or treatment with MRA
• Understands oral and written information and provides oral and written informed consent.
Locations
Other Locations
Sweden
University of Gothenburg
RECRUITING
Gothenburg
Karolinska University Hospital, Stockholm, Sweden.
NOT_YET_RECRUITING
Stockholm
Umeå University, Umeå, Sweden.
NOT_YET_RECRUITING
Umeå
Contact Information
Primary
Oskar Ragnarsson, MD
oskar.ragnarsson@medic.gu.se
00460313421000
Time Frame
Start Date: 2023-04-28
Estimated Completion Date: 2028-05-28
Participants
Target number of participants: 80
Treatments
Active_comparator: Surgically Treated Primary Aldosteronism
Standard therapy
Active_comparator: Medically Treated Unilateral Primary Aldosteronism
Open label eplerenone treatment
Related Therapeutic Areas
Sponsors
Collaborators: Karolinska Institutet, Umeå University
Leads: Göteborg University